Lilleyman J S, Harrison J F, Black J A
Blood. 1977 Apr;49(4):559-62.
Three cases of the juvenile type of chronic myeloid leukemia are described, all of which have shown a clinical and hematologic response to repeated cycles of sequential subcutaneous cytarabine and oral mercaptopurine. It appears that this regime, as described, may afford some control of a disease process previously supposed to be unresponsive to chemotherapy. This control, however, is likely to be reflected in an improvement in well-being, rather than overall survival time. Patient 1 survived 26 mo from diagnosis, and patients 2 and 3 are alive and well 12 and 9 mo from diagnosis, respectively.
本文描述了三例青少年型慢性粒细胞白血病病例，所有病例对皮下注射阿糖胞苷和口服巯嘌呤的序贯重复疗程均表现出临床和血液学反应。似乎如所述的这种治疗方案可能对先前认为对化疗无反应的疾病进程有一定控制作用。然而，这种控制可能体现在患者健康状况的改善上，而非总体生存时间的延长。患者1自诊断后存活了26个月，患者2和患者3自诊断后分别已存活12个月和9个月，目前状况良好。
