Wong Sio Leng, Leong Sok Man, Chan Cheng Man, Kan Sut Peng, Cheng Hon Wai Benjamin
1 Hospice & Palliative Care Centre, Kiang Wu Hospital, Macau, China.
2 Kiang Wu Nursing College of Macau, Macau, China.
Am J Hosp Palliat Care. 2017 Feb;34(1):42-46. doi: 10.1177/1049909115615127. Epub 2016 Jul 11.
Fan therapy is often suggested for relieving the symptom of dyspnea in patients with advanced cancer, but relevant literature among Asians is limited.
Phase 2 clinical trial to assess the clinical feasibility and outcome of using an electric fan to alleviate the symptom of dyspnea in Chinese patients with advanced cancer.
Thirty patients with advanced cancer having unresolved breathlessness were recruited from Hospice and Palliative Care Centre of Kiang Wu Hospital in Macau. Participants were randomly and equally allocated to the experimental group and the control group, respectively.
Verbal numerical rating scale (NRS) of breathlessness, respiratory rate (RR), and saturation of peripheral oxygen (SpO) was collected before and after the intervention.
T test was used to analyze the data collected. There was a significant difference in the NRS scores of the experimental group ( P < .01), indicating a significant reduction in the patients' sensation of breathlessness after fan therapy, whereas no significant difference was found in the objective statistic results of RR and SpO. No significant difference ( P > .05) was found in the control group for all the 3 variables before and after routine treatment.
The results of the study suggested that fan therapy could be effective in alleviating dyspnea in Chinese patients with advanced cancer. It should be considered as one of the nonpharmacological treatment option. Future large-scale phase 3 clinical trials are warranted.
风扇疗法常被建议用于缓解晚期癌症患者的呼吸困难症状,但亚洲人群中的相关文献有限。
进行一项2期临床试验,以评估使用电风扇缓解中国晚期癌症患者呼吸困难症状的临床可行性和效果。
从澳门镜湖医院善终及缓和医疗中心招募30例有未缓解呼吸困难症状的晚期癌症患者。参与者被随机且等分为试验组和对照组。
在干预前后收集呼吸困难的言语数字评定量表(NRS)、呼吸频率(RR)和外周血氧饱和度(SpO)。
采用t检验分析所收集的数据。试验组的NRS评分有显著差异(P <.01),表明风扇疗法后患者的呼吸困难感觉显著减轻,而RR和SpO的客观统计结果无显著差异。对照组在常规治疗前后,这3个变量均无显著差异(P >.05)。
研究结果表明,风扇疗法可有效缓解中国晚期癌症患者的呼吸困难。应将其视为非药物治疗选择之一。未来有必要进行大规模的3期临床试验。