Kohli Rakhi, Winston Diana, Sheehan Heidi, Muzzio Estela, Benetucci Jorge, Weissenbacher Mercedes, Wanke Christine, Knox Tamsin, Tang Alice
Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA, USA
Division of Gastroenterology, Tufts Medical Center, Boston, MA, USA.
J Int Assoc Provid AIDS Care. 2016 Sep;15(5):400-5. doi: 10.1177/2325957415614650. Epub 2015 Oct 30.
Improved understanding of cholesterol levels in HIV- and hepatitis C virus (HCV)-infected persons in Argentina will guide optimal antiretroviral therapy. The authors conducted a cross-sectional study in Argentina to describe associations between HIV, HCV, and cholesterol. Of the 202 participants, 21 were HIV infected, 15 were HCV infected, 46 were HIV/HCV coinfected, and 120 were HIV/HCV uninfected. HIV/HCV-uninfected participants had the highest total cholesterol (TC) and low-density lipoprotein (LDL) levels. Multivariate modeling revealed that HIV/HCV-coinfected patients had the lowest TC levels (-28.7 mg/dL, P < .001) compared to the HIV/HCV-uninfected reference group. Hepatitis C virus and HIV/HCV coinfection were associated with lower LDL levels (-21.4 mg/dL, P = .001 and -20.3 mg/dL, P < .0001, respectively). HIV and HIV/HCV coinfection, but not HCV alone, were associated with lower high-density lipoprotein levels (-9.1 mg/dL, P = .0008 and -6.8 mg/dL, P = .0006, respectively). Further study is needed to examine whether the more favorable lipid profile observed in HIV/HCV-coinfected persons is associated with a reduction in cardiovascular risk.
对阿根廷艾滋病毒和丙型肝炎病毒（HCV）感染者胆固醇水平的进一步了解将指导最佳抗逆转录病毒治疗。作者在阿根廷进行了一项横断面研究，以描述艾滋病毒、丙型肝炎病毒与胆固醇之间的关联。在202名参与者中，21人感染艾滋病毒，15人感染丙型肝炎病毒，46人同时感染艾滋病毒/丙型肝炎病毒，120人未感染艾滋病毒/丙型肝炎病毒。未感染艾滋病毒/丙型肝炎病毒的参与者总胆固醇（TC）和低密度脂蛋白（LDL）水平最高。多变量建模显示，与未感染艾滋病毒/丙型肝炎病毒的参照组相比，同时感染艾滋病毒/丙型肝炎病毒的患者TC水平最低（-28.7mg/dL，P<.001）。丙型肝炎病毒感染和艾滋病毒/丙型肝炎病毒合并感染与较低的低密度脂蛋白水平相关（分别为-21.4mg/dL，P=.001和-20.3mg/dL，P<.0001）。艾滋病毒感染和艾滋病毒/丙型肝炎病毒合并感染，但不包括单独的丙型肝炎病毒感染，与较低的高密度脂蛋白水平相关（分别为-9.1mg/dL，P=.0008和-6.8mg/dL，P=.0006）。需要进一步研究，以检查在同时感染艾滋病毒/丙型肝炎病毒的人群中观察到的更有利的血脂状况是否与心血管风险降低有关。
