口服抗糖尿病药物中毒的已故供体胰腺移植成功：一例报告

Successful Pancreas Transplantation From a Deceased Donor Intoxicated With Oral Antidiabetic Agent: A Case Report.

作者信息

Rodríguez-Villar C, Conget I, Ferrer-Fàbrega J, Paredes D, Ruíz A, Roque R, Rull R, López-Boado M, Ricart M J, Garcia R, Adalia R

机构信息

Sección de Donación y Coordinación de Trasplantes, Barcelona, Spain.

Unidad de Diabetes, Servicio de Endocrinología y Nutición, Barcelona, Spain.

出版信息

Transplant Proc. 2015 Oct;47(8):2404-6. doi: 10.1016/j.transproceed.2015.08.028.

DOI:10.1016/j.transproceed.2015.08.028

PMID:26518941

Abstract

Simultaneous kidney pancreas transplantation (SKP) is a common procedure for the patient with long-term type 1 diabetes mellitus (DM) with terminal renal failure. It is unusual to consider the pancreas from a deceased donor who died after an acute intoxication with oral antidiabetic agent (OAA), which would suggest an abnormal functionality of the organ and preclude the potential use of the graft. We present a case of a successful pancreatic transplantation from a donor who died of acute cerebral edema secondary to severe hypoglycemia induced by OAA acute intoxication.

摘要

同期肾胰联合移植（SKP）是终末期肾衰竭的长期1型糖尿病（DM）患者的常见手术。考虑使用死于口服抗糖尿病药物（OAA）急性中毒的脑死亡供体的胰腺是不寻常的，这表明该器官功能异常，可能无法进行移植。我们报告了一例成功的胰腺移植病例，供体死于OAA急性中毒所致严重低血糖继发的急性脑水肿。