Burridge Keith, Guilluy Christophe
Department of Cell Biology and Physiology, and Lineberger Comprehensive Cancer Center, 12-016 Lineberger, CB#7295, University of North Carolina, Chapel Hill, NC, USA.
Inserm UMR_S1087, CNRS UMR_C6291, L'institut du Thorax, and Université de Nantes, Nantes, France.
Exp Cell Res. 2016 Apr 10;343(1):14-20. doi: 10.1016/j.yexcr.2015.10.029. Epub 2015 Oct 28.
Stress fibers and focal adhesions are complex protein arrays that produce, transmit and sense mechanical tension. Evidence accumulated over many years led to the conclusion that mechanical tension generated within stress fibers contributes to the assembly of both stress fibers themselves and their associated focal adhesions. However, several lines of evidence have recently been presented against this model. Here we discuss the evidence for and against the role of mechanical tension in driving the assembly of these structures. We also consider how their assembly is influenced by the rigidity of the substratum to which cells are adhering. Finally, we discuss the recently identified connections between stress fibers and the nucleus, and the roles that these may play, both in cell migration and regulating nuclear function.
应力纤维和粘着斑是复杂的蛋白质阵列，它们产生、传递和感知机械张力。多年积累的证据得出结论，应力纤维内产生的机械张力有助于应力纤维自身及其相关粘着斑的组装。然而，最近有几条证据对该模型提出了质疑。在这里，我们讨论支持和反对机械张力在驱动这些结构组装中作用的证据。我们还考虑细胞粘附的基质刚度如何影响它们的组装。最后，我们讨论最近发现的应力纤维与细胞核之间的联系，以及它们在细胞迁移和调节核功能中可能发挥的作用。
