Saeidi Alireza, Buggert Marcus, Che Karlhans F, Kong Yong Y, Velu Vijayakumar, Larsson Marie, Shankar Esaki M
Centre of Excellence for Research in AIDS (CERiA), Faculty of Medicine, University of Malaya, Lembah Pantai, Kuala Lumpur, Malaysia.
Department of Microbiology, University of Pennsylvania, USA.
Cell Immunol. 2015 Nov-Dec;298(1-2):126-33. doi: 10.1016/j.cellimm.2015.10.009. Epub 2015 Oct 24.
Understanding the mechanisms involved in cellular immune responses against control of human immunodeficiency virus (HIV) infection is key to development of effective immunotherapeutic strategies against viral proliferation. Clear insights into the regulation of cytotoxic CD8+ T cells is crucial to development of effective immunotherapeutic strategies due to their unique ability to eliminate virus-infected cells during the course of infection. Here, we reviewed the roles of transcription factors, co-inhibitory molecules and regulatory cytokines following HIV infection and their potential significance in regulating the cytotoxic potentials of CD8+ T cells.
了解细胞免疫反应中涉及的对抗人类免疫缺陷病毒（HIV）感染控制的机制，是开发针对病毒增殖的有效免疫治疗策略的关键。深入了解细胞毒性CD8 + T细胞的调节对于开发有效的免疫治疗策略至关重要，因为它们在感染过程中具有消除病毒感染细胞的独特能力。在这里，我们综述了HIV感染后转录因子、共抑制分子和调节性细胞因子的作用及其在调节CD8 + T细胞细胞毒性潜能方面的潜在意义。
