Enantioselective hydrogenation of cyclic imines catalysed by Noyori-Ikariya half-sandwich complexes and their analogues.

作者信息

Vilhanová B, Václavík J, Šot P, Pecháček J, Zápal J, Pažout R, Maixner J, Kuzma M, Kačer P

机构信息

Department of Organic Technology, University of Chemistry and Technology, Technická 5, CZ-166 28 Prague, Czech Republic.

出版信息

Chem Commun (Camb). 2016 Jan 7;52(2):362-5. doi: 10.1039/c5cc06712j. Epub 2015 Nov 2.

A method for enantioselective hydrogenation of cyclic imines with gaseous hydrogen has been developed. Easily accessible Noyori-Ikariya Ru(II) and Rh(III) complexes can be used directly without an inert atmosphere. Substrate activation has been achieved by trifluoroacetic acid. A new hydroxyl-functionalized complex is reported, showing high activity in transfer hydrogenation.