Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Venezian 21, 20133 Milano, Italy.
Molecules. 2019 Jul 30;24(15):2771. doi: 10.3390/molecules24152771.
The chiral structure of antibiotic vancomycin (Van) was exploited as an innovative coordination sphere for the preparation of an IrCp* based hybrid catalysts. We found that Van is able to coordinate iridium (Ir(III)) and the complexation was demonstrated by several analytical techniques such as MALDI-TOF, UV, Circular dichroism (CD), Raman IR, and NMR. The hybrid system so obtained was employed in the Asymmetric Transfer Hydrogenation (ATH) of cyclic imines allowing to obtain a valuable 61% () in the asymmetric reduction of quinaldine . The catalytic system exhibited a saturation kinetics with a calculated efficiency of K/K = 0.688 hmM.
万古霉素（Van）的手性结构被用作一种创新的配位体，用于制备基于 IrCp*的杂化催化剂。我们发现 Van 能够与铱（Ir(III)）配位，这种配位作用通过 MALDI-TOF、UV、圆二色性（CD）、拉曼 IR 和 NMR 等多种分析技术得到了证明。所得到的杂化体系被用于环状亚胺的不对称转移氢化（ATH）中，从而在喹啉的不对称还原中获得了有价值的 61%ee（）。该催化体系表现出饱和动力学，计算效率为 K/K = 0.688 hmM。
