Funakoshi A, Miyasaka K, Kitani K, Tatemoto K
National Kyushu Cancer Center, Fukuoka, Japan.
Regul Pept. 1989 Mar;24(3):225-31. doi: 10.1016/0167-0115(89)90219-x.
We have studied the effects of pancreastatin on insulin and glucagon secretions in vivo in the conscious rat. Rats were prepared with a gastric fistula and with both external jugular veins cannulated. We found that an i.v. infusion of pancreastatin (1 and 10 nmol/kg/h) inhibited the plasma insulin response and increased the plasma glucose response to the intragastric infusion of glucose in a dose-dependent manner. Furthermore, the infusion of pancreastatin increased the plasma glucagon response to the i.v. infusion of arginine in a dose-dependent manner, and it inhibited the plasma insulin response. However, such an infusion of pancreastatin had no effect on the basal plasma glucose level, nor did it have any effect on plasma insulin and glucagon concentrations. Thus, it is suggested that in the rat, the newly discovered pancreastatin is a regulator of islet cell function.
我们研究了胰抑制素对清醒大鼠体内胰岛素和胰高血糖素分泌的影响。大鼠制备了胃瘘并将双侧颈外静脉插管。我们发现静脉输注胰抑制素（1和10 nmol/kg/h）以剂量依赖的方式抑制血浆胰岛素反应，并增加对胃内输注葡萄糖的血浆葡萄糖反应。此外，输注胰抑制素以剂量依赖的方式增加对静脉输注精氨酸的血浆胰高血糖素反应，并抑制血浆胰岛素反应。然而，这种胰抑制素输注对基础血浆葡萄糖水平没有影响，对血浆胰岛素和胰高血糖素浓度也没有任何影响。因此，提示在大鼠中，新发现的胰抑制素是胰岛细胞功能的调节因子。
