Holst J J, Ostenson C G, Harling H, Messell T
Institute of Medical Physiology C, Panum Institute, University of Copenhagen, Denmark.
Diabetologia. 1990 Jul;33(7):403-6. doi: 10.1007/BF00404088.
We investigated the effects of porcine pancreastatin on the endocrine and unstimulated exocrine secretion of isolated, perfused porcine pancreas. Pancreastatin in a concentration of 10(-8) mol/l had no effect on basal secretion of insulin, glucagon and somatostatin at a perfusate glucose concentration of 5 mmol/l (n = 4) and neither at 10(-8) nor 10(-7) mol/l influenced the hormone responses to acute elevations of perfusate glucose concentration from 3.5 to 11 mmol/l (n = 7). This elevation strongly stimulated insulin secretion and inhibited glucagon secretion. Exocrine secretion was not affected by pancreastatin. The results suggest that pancreastatin does not directly influence pancreatic secretion.
我们研究了猪胰抑制素对离体灌注猪胰腺内分泌和非刺激外分泌的影响。在灌注液葡萄糖浓度为5 mmol/l时，浓度为10(-8) mol/l的胰抑制素对胰岛素、胰高血糖素和生长抑素的基础分泌没有影响（n = 4），在10(-8) mol/l和10(-7) mol/l时，也不影响激素对灌注液葡萄糖浓度从3.5 mmol/l急性升高到11 mmol/l的反应（n = 7）。这种升高强烈刺激胰岛素分泌并抑制胰高血糖素分泌。外分泌不受胰抑制素影响。结果表明，胰抑制素不直接影响胰腺分泌。
