女性年龄对高反应者新鲜周期及随后使用玻璃化囊胚的冷冻周期累积活产率的影响。
The influence of female age on the cumulative live-birth rate of fresh cycles and subsequent frozen cycles using vitrified blastocysts in hyper-responders.
作者信息
Wu Cheng-Hsuan, Lee Tsung-Hsien, Chen Hsiu-Hui, Chen Chung-I, Huang Chun-Chia, Lee Maw-Sheng
机构信息
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan.
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan.
出版信息
Taiwan J Obstet Gynecol. 2015 Oct;54(5):567-71. doi: 10.1016/j.tjog.2015.08.009.
OBJECTIVE
The aim of this research was to study the influence of female age on the cumulative live-birth rate of fresh and subsequent frozen cycles using vitrified blastocysts of the same cohort in hyper-responders.
MATERIALS AND METHODS
This was a retrospective study of 1137 infertile women undergoing their first in vitro fertilization treatment between 2006 and 2013. The main outcome measure was cumulative live births among the fresh and all vitrified blastocyst transfers combined after the same stimulation cycle. The results were also analyzed according to age (i.e., <35 years, 35-39 years, and ≥ 40 years).
RESULTS
The mean number of retrieved oocytes was 19.9 ± 8.5 oocytes. The cumulative pregnancy rate was 89.2% and the cumulative live-birth rate was 73.3%. The cumulative live-birth rate declined from 73.9% for women younger than 35 years old to 67.3% for women 35-39 years old to 57.9% for women 40 years or older.
CONCLUSION
Combined fresh and vitrified blastocyst transfer cycles can result in a high cumulative live-birth rate. The cumulative live-birth rates among older women are lower than the rates among younger women when autologous oocytes are used.
目的
本研究旨在探讨女性年龄对高反应者同一队列玻璃化囊胚新鲜周期及后续冷冻周期累积活产率的影响。
材料与方法
这是一项对2006年至2013年间接受首次体外受精治疗的1137名不孕女性的回顾性研究。主要观察指标为同一刺激周期后新鲜周期及所有玻璃化囊胚移植后的累积活产情况。结果还根据年龄（即<35岁、35 - 39岁和≥40岁）进行了分析。
结果
平均获卵数为19.9±8.5个。累积妊娠率为89.2%，累积活产率为73.3%。累积活产率从<35岁女性的73.9%下降至35 - 39岁女性的67.3%，再降至40岁及以上女性的57.9%。
结论
新鲜周期与玻璃化囊胚移植周期相结合可获得较高的累积活产率。使用自体卵子时，老年女性的累积活产率低于年轻女性。
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