载有舒尼替尼的壳聚糖纳米粒制剂及其评价。
Sunitinib loaded chitosan nanoparticles formulation and its evaluation.
作者信息
Joseph Jayapal John, Sangeetha D, Gomathi Thandapani
机构信息
Environmental & Analytical Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632 014, Tamil Nadu, India.
Department of Chemistry, D.K.M. College for Women, Vellore 632 001, Tamil Nadu, India.
出版信息
Int J Biol Macromol. 2016 Jan;82:952-8. doi: 10.1016/j.ijbiomac.2015.10.079. Epub 2015 Oct 29.
The nano-polymeric pharmaceutical excipient such as chitosan nanoparticles (CS-NPs) were synthesized for formulating the anticancer drug Sunitinib (STB). The formulation was done through the simple ionic cross linking method. The prepared formulation was characterized by DLS, SEM, FT-IR and XRD. The DLS study reveals that the Sunitinib loaded chitosan nanoparticles (SNB-CS-NPs) were in the size range of < 200 nm. Encapsulation of Sunitinib and validation for the formulation was done using UV spectrophotometry. In vitro drug release and its cytotoxic studies were performed for STB-CS-NPs. This study implies the novel drug delivery system for Sunitinib for the effective sustained delivery.
合成了纳米聚合药物赋形剂，如壳聚糖纳米颗粒（CS-NPs），用于配制抗癌药物舒尼替尼（STB）。该制剂通过简单的离子交联法制备。通过动态光散射（DLS）、扫描电子显微镜（SEM）、傅里叶变换红外光谱（FT-IR）和X射线衍射（XRD）对制备的制剂进行了表征。DLS研究表明，负载舒尼替尼的壳聚糖纳米颗粒（SNB-CS-NPs）尺寸范围小于200nm。使用紫外分光光度法对舒尼替尼进行包封并验证制剂。对STB-CS-NPs进行了体外药物释放及其细胞毒性研究。该研究表明了用于舒尼替尼有效持续递送的新型药物递送系统。
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