Baranyi Marcell, Lippai Mónika, Szatmári Zsuzsanna
Anatómiai, Sejt- és Fejlődésbiológiai Tanszék, Eötvös Loránd Tudományegyetem Budapest.
Orv Hetil. 2015 Nov 8;156(45):1816-23. doi: 10.1556/650.2015.30294.
In the last decade, growing attention was paid to the observation that tumors did not only consist of cancer cells, they are rather a complex tissue-like mixture of tumor and stromal cells, which are playing an important role in the course of the malignant disease. Their contribution is so essential that without them, tumors are not even able to grow. This short review summarizes how stromal cells can promote the cancerous transformation and early development of tumors, how chronic inflammation contributes to the progression of cancer and how the stroma takes part in the induction of angiogenesis. The main mechanisms by which tumors can escape the immune surveillance will be demonstrated as well as the complex contributions of stroma to the invasion, intravasation and metastasis of cancer cells. Finally, possible and promising therapies will be presented that aim at the stroma and its main effects on the progression of tumors.
在过去十年中，人们越来越关注这样一种观察结果，即肿瘤不仅由癌细胞组成，它们更像是肿瘤细胞和基质细胞组成的复杂组织样混合物，这些细胞在恶性疾病的发展过程中发挥着重要作用。它们的作用至关重要，没有它们，肿瘤甚至无法生长。这篇简短的综述总结了基质细胞如何促进肿瘤的癌变和早期发展，慢性炎症如何促进癌症进展，以及基质如何参与诱导血管生成。还将阐述肿瘤逃避免疫监视的主要机制，以及基质对癌细胞侵袭、血管内渗和转移的复杂作用。最后，将介绍针对基质及其对肿瘤进展的主要影响的可能且有前景的治疗方法。
