Le Bitoux Marie-Aude, Stamenkovic Ivan
Division of Experimental Pathology, Institute of Pathology, CHUV, Lausanne, Switzerland.
Histochem Cell Biol. 2008 Dec;130(6):1079-90. doi: 10.1007/s00418-008-0527-3. Epub 2008 Oct 25.
It is well established that interactions between tumor cells and the host tissue stroma play a key role in determining whether and how any given solid malignancy will develop. In most cases, tumor cells hijack stromal cell functions for their own benefit and ultimately dictate the rules of engagement to the host tissue microenvironment. However, the contribution of the different stromal cell components to tumor growth remains to be clarified. Because most solid tumors are accompanied by a local inflammatory response, it has long been thought that inflammation and carcinogenesis are related. If formal proof that cancer can be initiated by inflammation in the absence of exogenous carcinogens is still lacking, there is abundant evidence that the inflammatory response can play a central role in modulating tumor growth and progression. This review will discuss some of the mechanisms whereby inflammation can both enhance and inhibit tumor growth.
肿瘤细胞与宿主组织基质之间的相互作用在决定任何特定实体恶性肿瘤是否会发生以及如何发生方面起着关键作用，这一点已得到充分证实。在大多数情况下，肿瘤细胞为自身利益劫持基质细胞功能，并最终决定与宿主组织微环境的相互作用规则。然而，不同基质细胞成分对肿瘤生长的贡献仍有待阐明。由于大多数实体瘤都伴有局部炎症反应，长期以来人们一直认为炎症与致癌作用有关。如果仍然缺乏在没有外源性致癌物的情况下炎症可引发癌症的确切证据，那么有大量证据表明炎症反应在调节肿瘤生长和进展中可发挥核心作用。本综述将讨论炎症既能促进又能抑制肿瘤生长的一些机制。
