Liu Xing-Hai, Zhai Zhi-Wen, Xu Xiao-Yan, Yang Ming-Yan, Sun Zhao-Hui, Weng Jian-Quan, Tan Cheng-Xia, Chen Jie
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
Bioorg Med Chem Lett. 2015 Dec 1;25(23):5524-8. doi: 10.1016/j.bmcl.2015.10.064. Epub 2015 Oct 23.
A series of novel 1,2,4-triazolo[4,3-a]pyridin-3(2H)-one derivatives were synthesized and identified by (1)H NMR, single crystal X-ray diffraction, elemental analysis or HRMS, and their herbicidal activities were determined at different concentrations. It was found that some of the title compounds possess high herbicidal activity. Furthermore, DFT calculation was used to study the SAR.
合成了一系列新型1,2,4-三唑并[4,3-a]吡啶-3(2H)-酮衍生物，并通过核磁共振氢谱、单晶X射线衍射、元素分析或高分辨质谱对其进行了鉴定，同时测定了它们在不同浓度下的除草活性。结果发现，部分目标化合物具有较高的除草活性。此外，还采用密度泛函理论计算对其构效关系进行了研究。
