Sharma Amy C, Turkington Timothy G, Tourassi Georgia D, Floyd Carey E
Duke Advanced Imaging Laboratories, Duke University Medical Center, Durham, NC 27705 ; Department of Radiology, Duke University Medical Center, Durham, NC 27705.
Department of Radiology, Duke University Medical Center, Durham, NC 27705.
Nucl Instrum Methods Phys Res B. 2008 Nov;266(22):4938-47. doi: 10.1016/j.nimb.2008.07.036.
Certain trace elements are vital to the body and elemental imbalances can be indicators of certain diseases including cancer and liver diseases. Neutron Stimulated Emission Computed Tomography (NSECT) is being developed as spectroscopic imaging technique to non-invasively and non-destructively measure and image elemental concentrations within the body. A region of interest is illuminated via a high-energy beam of neutrons that scatter inelastically with elemental nuclei within the body. The excited nuclei then relax by emitting characteristic gamma rays. Acquiring the gamma spectrum in a tomographic manner allows not only the identification of elements, but also the formation of images representing spatial distributions of specific elements. We are developing a high-energy position-sensitive gamma camera that allows full illumination of the entire region of interest. Because current scintillation crystal based position-sensitive gamma cameras operate in too low of an energy range, we are adapting high-energy gamma imaging techniques used in space-based imaging. A High Purity Germanium (HPGe) detector provides high-resolution energy spectra while a rotating modulation collimator (RMC) placed in front of the detector modulates the incoming signal to provide spatial information. The purpose of this manuscript is to describe the near-field RMC geometry, which varies greatly from the infinite-focus space-based applications, and how it modulates the incident gamma flux. A simple geometric model is presented and then used to reconstruct two-dimensional planar images of both simulated point sources and extended sources.
某些微量元素对人体至关重要,元素失衡可能是包括癌症和肝脏疾病在内的某些疾病的指标。中子激发发射计算机断层扫描(NSECT)正在被开发为一种光谱成像技术,用于非侵入性和非破坏性地测量和成像体内的元素浓度。通过高能中子束照射感兴趣区域,中子与体内的元素核发生非弹性散射。被激发的核随后通过发射特征伽马射线而弛豫。以断层扫描方式获取伽马谱不仅可以识别元素,还可以形成表示特定元素空间分布的图像。我们正在开发一种高能位置敏感伽马相机,它可以对整个感兴趣区域进行全面照射。由于目前基于闪烁晶体的位置敏感伽马相机在过低的能量范围内工作,我们正在采用用于天基成像的高能伽马成像技术。高纯度锗(HPGe)探测器提供高分辨率能谱,而置于探测器前方的旋转调制准直器(RMC)对入射信号进行调制以提供空间信息。本文的目的是描述近场RMC几何结构,它与无限聚焦天基应用有很大不同,以及它如何调制入射伽马通量。提出了一个简单的几何模型,然后用于重建模拟点源和扩展源的二维平面图像。