Kunnas Tarja, Määttä Kirsi, Nikkari Seppo T
Department of Medical Biochemistry, University of Tampere Medical School and Fimlab laboratories, Tampere, Finland.
Immun Ageing. 2015 Oct 31;12:19. doi: 10.1186/s12979-015-0047-7. eCollection 2015.
The activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome by cellular stress leads to activation of the inflammasome, and NLRP3 gene polymorphisms have been associated with autoinflammatory diseases. Inflammasomes have also been implicated in the initiation or progression of metabolic disorders such as atherosclerosis, type 2 diabetes and obesity. The association of NLRP3 genetic variant rs7512998 with blood pressure and hypertension was studied in a 50-year-old Finnish cohort with a subpopulation who had available data on blood pressure measurements also at the age of 45 years.
NLRP3 gene polymorphism rs7512998 C-allele was associated with higher systolic (p = 0.006) and diastolic (p = 0.011) blood pressure compared to the TT-genotype carriers in 50-year-old subjects. In addition, by analysis of variance for repeated measures between ages of 45- and 50 years there was a significant time by genotype interaction; blood pressure increased more in subjects with the C-allele both in systolic (p = 0.035) and diastolic (p = 0.012) values. However, no association with diagnosed hypertension was found.
We report for the first time that NLRP3 gene polymorphism rs7512998 was associated with systolic and diastolic blood pressure in 50-year-old subjects. In addition, an effect of this variation upon blood pressure was seen in these same subjects in a 5-year follow-up from a 45-year-old cohort to 50 years of age.
细胞应激激活含NLR家族pyrin结构域蛋白3（NLRP3）炎性小体可导致炎性小体活化，且NLRP3基因多态性与自身炎症性疾病相关。炎性小体也与动脉粥样硬化、2型糖尿病和肥胖等代谢紊乱的发生或发展有关。在一个50岁的芬兰队列中，对NLRP3基因变异rs7512998与血压及高血压的关联进行了研究，该队列中的一个亚组在45岁时也有血压测量数据。
在50岁的受试者中，与TT基因型携带者相比，NLRP3基因多态性rs7512998的C等位基因与更高的收缩压（p = 0.006）和舒张压（p = 0.011）相关。此外，通过对45岁至50岁之间重复测量的方差分析，发现存在显著的基因型与时间交互作用；携带C等位基因的受试者收缩压（p = 0.035）和舒张压（p = 0.012）的升高幅度更大。然而，未发现与确诊高血压有关联。
我们首次报告，NLRP3基因多态性rs7512998与50岁受试者的收缩压和舒张压相关。此外，在一个从45岁到50岁的5年随访队列中，同一批受试者中也观察到了这种变异对血压的影响。
