Mahmood Shahid, Bhatti Attya, Syed Nida Ali, John Peter
a Immunogenetic Lab, Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Science and Technology (NUST) , Islamabad , Pakistan.
J Recept Signal Transduct Res. 2016;36(3):310-8. doi: 10.3109/10799893.2015.1080273. Epub 2015 Nov 2.
Wnt signaling pathway plays an important role in cell renewal, tumorigenesis, organogenesis, bone formation and bone resorption. Wnt signaling pathway is divided into two outlets: Wnt-β-catenin pathway (canonical pathway) and Wnt-calcium pathway (non-canonical pathway). miRNAs play a key role in the regulation of Wnt signaling pathway. In this review, we highlight the basic indulgent of miRNAs-mediated regulation of Wnt signaling pathway. We focus on the role of miRNAs at different levels of Wnt signaling: signaling molecules, their associated signaling proteins, regulatory proteins, transcription factors and related cytokines. Finally, we concluded that these multiple levels of targeting may have diagnostic potential as well as therapeutic prospective in future treatment.
Wnt信号通路在细胞更新、肿瘤发生、器官发生、骨形成和骨吸收中发挥着重要作用。Wnt信号通路分为两个分支：Wnt-β-连环蛋白通路（经典通路）和Wnt-钙通路（非经典通路）。微小RNA（miRNAs）在Wnt信号通路的调控中起关键作用。在本综述中，我们重点介绍了miRNAs介导的Wnt信号通路调控的基本情况。我们关注miRNAs在Wnt信号通路不同水平上的作用：信号分子、其相关的信号蛋白、调节蛋白、转录因子和相关细胞因子。最后，我们得出结论，这些多层次的靶向作用在未来治疗中可能具有诊断潜力和治疗前景。
