Nitsche María Pía, Carreño Monica
Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile. Address: Lira 63, Santiago Centro, Chile. Email:
Proyecto Epistemonikos, Santiago, Chile; Departamento de Pediatría, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Medwave. 2015 Oct 29;15 Suppl 2:e6295. doi: 10.5867/medwave.2015.6295.
Acute otitis media is one of the most common infectious diseases diagnosed in children. Antibiotic treatment use remains controversial. This summary aims to evaluate the effectiveness and safety of antibiotics in children with acute otitis media. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified six systematic reviews including 18 randomized trials. We combined the evidence using meta-analysis and generated a summary of findings table following the GRADE approach. We concluded antibiotics reduce pain at 48-72 hours and reduce the risk of tympanic perforations in children with acute otitis media, but they do not reduce late recurrences and increase the risk of side effects (rash, vomiting and diarrhea).
急性中耳炎是儿童中诊断出的最常见传染病之一。抗生素治疗的使用仍存在争议。本综述旨在评估抗生素治疗急性中耳炎患儿的有效性和安全性。通过检索由筛选30个数据库维护的Epistemonikos数据库，我们确定了6项系统评价，包括18项随机试验。我们使用荟萃分析合并证据，并按照GRADE方法生成了结果总结表。我们得出结论，抗生素可减轻急性中耳炎患儿48 - 72小时的疼痛，并降低鼓膜穿孔的风险，但不会降低后期复发率，且会增加副作用（皮疹、呕吐和腹泻）的风险。
