Fuke Tomonori, Takahashi Tohru, Yamada Yoshiyuki, Miyashita Mitsuhiro, Amano Naoji, Matsushita Masaaki
Seishin Shinkeigaku Zasshi. 2015;117(4):257-68.
A large number of case studies on Cotard's syndrome have reported that this syndrome develops after repeated episodes of depression in the presenile stage of life. Therefore, it has been defined as a severe type of affective spectrum disorder. This report describes three patients who exhibited symptoms characteristic of Cotard's syndrome, such as negative thoughts and delusions of immortality, in the presenile and senile stages of their lives. They also had a history of long-term treatment for schizophrenia based on a diagnosis in early adulthood. Our review of reports on Cotard's syndrome revealed that the syndrome is more prevalent among presenile and senile female patients, who initially visit psychiatrists in their involutional and presenile stages of life with symptoms of an affective spectrum disorder, and later exhibit the symptoms of Cotard's syndrome. The results of the three case studies suggest that biological factors related to aging and sex differences may be associated with the development of Cotard's syndrome, regardless of the primary disorder. The pathology of "involutional and senile-onset endogenous psychosis," including Cotard's syndrome, is also discussed.
大量关于科塔尔综合征的病例研究报告称，该综合征在生命的老年前期反复出现抑郁发作后发展而来。因此，它被定义为一种严重类型的情感谱系障碍。本报告描述了三名患者，他们在生命的老年前期和老年期表现出科塔尔综合征的特征性症状，如消极思想和不朽妄想。他们在成年早期被诊断为精神分裂症后，还有长期治疗史。我们对科塔尔综合征报告的回顾显示，该综合征在老年前期和老年女性患者中更为普遍，她们在更年期和老年前期阶段因情感谱系障碍症状首次就诊于精神科医生，随后出现科塔尔综合征的症状。这三个病例研究的结果表明，无论原发性疾病如何，与衰老和性别差异相关的生物学因素可能与科塔尔综合征的发生有关。还讨论了包括科塔尔综合征在内的“更年期和老年期内源性精神病”的病理学。
