Benson Robert, Berry David, Lockey James, Brattin William, Hilbert Timothy, LeMasters Grace
Environmental Protection Agency, 1595 Wynkoop St, Denver, CO, 80202, United States.
Environmental Protection Agency, 1595 Wynkoop St, Denver, CO, 80202, United States.
Regul Toxicol Pharmacol. 2015 Dec;73(3):780-9. doi: 10.1016/j.yrtph.2015.10.019. Epub 2015 Oct 23.
The United States Environmental Protection Agency (EPA) developed a quantitative exposure-response model for the non-cancer effects of Libby Amphibole Asbestos (LAA) (EPA, 2014). The model is based on the prevalence of localized pleural thickening (LPT) in workers exposed to LAA at a workplace in Marysville, Ohio (Lockey et al., 1984; Rohs et al., 2008). Recently, Lockey et al. (2015a) published a follow-up study of surviving Marysville workers. The data from this study increases the number of cases of LPT and extends the observation period for a number of workers, thereby providing a strengthened data set to define and constrain the optimal exposure-response model for non-cancer effects from inhalation exposure to LAA. The new data were combined with the previous data to update the exposure-response modeling for LPT. The results indicate that a bivariate model using cumulative exposure and time since first exposure is appropriate, and the benchmark concentration is similar to the findings previously reported by EPA (2014). In addition, the data were also used to develop initial exposure-response models for diffuse pleural thickening (DPT) and small interstitial opacities (SIO).
美国环境保护局（EPA）针对利比角闪石石棉（LAA）的非致癌效应开发了一种定量暴露-反应模型（EPA，2014年）。该模型基于俄亥俄州玛丽斯维尔一个工作场所中接触LAA的工人局部胸膜增厚（LPT）的患病率（洛基等人，1984年；罗斯等人，2008年）。最近，洛基等人（2015年a）发表了一项对玛丽斯维尔幸存工人的后续研究。这项研究的数据增加了LPT病例数量，并延长了一些工人的观察期，从而提供了一个更强有力的数据集来定义和限制吸入LAA所致非致癌效应的最佳暴露-反应模型。将新数据与先前数据相结合，以更新LPT的暴露-反应模型。结果表明，使用累积暴露量和首次暴露后时间的双变量模型是合适的，基准浓度与EPA先前（2014年）报告的结果相似。此外，这些数据还被用于开发弥漫性胸膜增厚（DPT）和小间质混浊（SIO）的初始暴露-反应模型。
