Baraille Floriane, Planchais Julien, Dentin Renaud, Guilmeau Sandra, Postic Catherine
Inserm U1016 Institut Cochin, Paris, France; CNRS UMR 8104, Paris, France; and Université Paris Descartes, Paris, France.
Inserm U1016 Institut Cochin, Paris, France; CNRS UMR 8104, Paris, France; and Université Paris Descartes, Paris, France
Physiology (Bethesda). 2015 Nov;30(6):428-37. doi: 10.1152/physiol.00016.2015.
Since glucose is the principal energy source for most cells, many organisms have evolved numerous and sophisticated mechanisms to sense glucose and respond to it appropriately. In this context, cloning of the carbohydrate responsive element binding protein has unraveled a critical molecular link between glucose metabolism and transcriptional reprogramming induced by glucose. In this review, we detail major findings that have advanced our knowledge of glucose sensing.
由于葡萄糖是大多数细胞的主要能量来源，许多生物体已经进化出众多复杂的机制来感知葡萄糖并做出适当反应。在这种情况下，碳水化合物反应元件结合蛋白的克隆揭示了葡萄糖代谢与葡萄糖诱导的转录重编程之间的关键分子联系。在这篇综述中，我们详细阐述了那些增进我们对葡萄糖感知认识的主要发现。
