[转录因子ChREBP——碳水化合物和脂质代谢的协调者]
[Transcription factor ChREBP – the coordinator of carbohydrate and lipid metabolism].
作者信息
Krawczak Joanna, Owczarek Aleksandra, Winiarska Katarzyna
机构信息
Zakład Regulacji Metabolizmu, Instytut Biochemii, Wydział Biologii, Uniwersytet Warszawski.
Department of Metabolic Regulation, Institute of Biochemistry, Faculty of Biology, University of Warsaw.
出版信息
Postepy Biochem. 2020 Jan 9;66(1):30-37. doi: 10.18388/pb.2019_282. Print 2020 Mar 31.
Transcription factor ChREBP, in complex with MLX, binds to carbohydrate-response element (ChoRE) located in the promoters of genes related to glycolysis, gluconeogenesis, pentosephosphate pathway and lipogenesis, activating their transcription following stimulation with glucose, insulin-independently. In this article the mechanisms of ChREBP regulation and ChREBP functions under both physiological and pathophysiological conditions are described in detail. The possible use of ChREBP activity modulation as a therapeutic tool, e.g. in case of nonalcoholic fatty liver disease, diabetes type 2 and cancers, is also discussed.
转录因子ChREBP与MLX形成复合物，与位于糖酵解、糖异生、磷酸戊糖途径和脂肪生成相关基因启动子中的碳水化合物反应元件（ChoRE）结合，在葡萄糖刺激后独立于胰岛素激活这些基因的转录。本文详细描述了ChREBP在生理和病理生理条件下的调节机制和功能。还讨论了调节ChREBP活性作为一种治疗工具的可能性，例如在非酒精性脂肪性肝病、2型糖尿病和癌症中的应用。
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