Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee. Center for Cancer Targeted Therapies, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
Center for Cancer Targeted Therapies, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee. Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee. Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.
Cancer Discov. 2015 Nov;5(11):1124-6. doi: 10.1158/2159-8290.CD-15-1166.
Two recent studies report deep molecular profiling of matched brain metastases and primary tumors. In both studies, somatic alterations in the brain metastases were frequently discordant with those in the primary tumor, suggesting divergent evolution at metastatic sites and raising questions about the use of biomarkers in patients in clinical trials with targeted therapies.
最近的两项研究报告了对配对的脑转移瘤和原发肿瘤进行的深度分子分析。在这两项研究中，脑转移瘤中的体细胞改变与原发肿瘤中的改变经常不一致，这表明转移部位存在不同的进化，并对在接受靶向治疗临床试验的患者中使用生物标志物提出了疑问。
