Berry Ryan, Rodeheffer Matthew S, Rosen Clifford J, Horowitz Mark C
Department of Orthopaedics and Rehabiliation, Yale School of Medicine, New Haven, CT 06510.
Department of Molecular, Cell and Developmental Biology, Yale University and the Section of Comparative Medicine, Yale School of Medicine, 375 Congress Avenue, New Haven, CT 06510.
Curr Mol Biol Rep. 2015 Sep;1(3):101-109. doi: 10.1007/s40610-015-0018-y. Epub 2015 Jul 12.
The formation of brown, white and beige adipocytes have been a subject of intense scientific interest in recent years due to the growing obesity epidemic in the United States and around the world. This interest has led to the identification and characterization of specific tissue resident progenitor cells that give rise to each adipocyte population in vivo. However, much still remains to be discovered about each progenitor population in terms of their "niche" within each tissue and how they are regulated at the cellular and molecular level during healthy and diseased states. While our knowledge of brown, white and beige adipose tissue is rapidly increasing, little is still known about marrow adipose tissue and its progenitor despite recent studies demonstrating possible roles for marrow adipose tissue in regulating the hematopoietic space and systemic metabolism at large. This chapter focuses on our current knowledge of brown, white, beige and marrow adipose tissue with a specific focus on the formation of each tissue from tissue resident progenitor cells.
由于美国及全球肥胖流行趋势日益严重，近年来棕色、白色和米色脂肪细胞的形成一直是科学界高度关注的课题。这种关注促使人们识别并表征了特定的组织驻留祖细胞，这些祖细胞在体内可产生每种脂肪细胞群体。然而，就每种祖细胞群体在各组织中的“生态位”，以及在健康和疾病状态下它们在细胞和分子水平如何受到调控而言，仍有许多有待发现之处。尽管最近的研究表明骨髓脂肪组织在调节造血空间和整体全身代谢方面可能发挥作用，但我们对骨髓脂肪组织及其祖细胞的了解仍然很少。本章重点介绍我们目前对棕色、白色、米色和骨髓脂肪组织的认识，特别关注每种组织由组织驻留祖细胞形成的过程。
