Melero-Jerez Carolina, Ortega María Cristina, Moliné-Velázquez Verónica, Clemente Diego
Grupo de Neurobiología del Desarrollo-GNDe, Hospital Nacional de Parapléjicos, Finca "La Peraleda" s/n, E-45071 Toledo, Spain.
Grupo de Neurobiología del Desarrollo-GNDe, Hospital Nacional de Parapléjicos, Finca "La Peraleda" s/n, E-45071 Toledo, Spain; Centro de Biología Molecular Severo Ochoa. Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, 28049 Madrid, Spain.
Biochim Biophys Acta. 2016 Mar;1862(3):368-80. doi: 10.1016/j.bbadis.2015.10.015. Epub 2015 Oct 23.
The knowledge of the immune system elements and their relationship with other tissues, organs and systems are key approximations for the resolution of many immune-related disorders. The control of the immune response and/or its modulation from the pro-inflammatory to the anti-inflammatory response is being deeply studied in the field. In the last years, the study of myeloid-derived suppressor cells (MDSCs), a group of immature myeloid cells with a high suppressive activity on T cells has been extensively addressed in cancer. In contrast, their role in neuroimmune diseases is far from being totally understood. In this review, we will summarize data about MDSCs coming from the study of neuroinflammatory diseases in general and their potential role in multiple sclerosis, in order to introduce the putative use of this extraordinary promising cell type for future cell-based therapies. This article is part of a Special Issue entitled: Neuro Inflammation edited by Helga E. de Vries and Markus Schwaninger.
了解免疫系统的组成部分及其与其他组织、器官和系统的关系，是解决许多免疫相关疾病的关键切入点。该领域正在深入研究免疫反应的控制和/或从促炎反应到抗炎反应的调节。近年来，髓系来源的抑制细胞（MDSCs），即一群对T细胞具有高抑制活性的未成熟髓系细胞，在癌症研究中得到了广泛关注。相比之下，它们在神经免疫疾病中的作用远未被完全理解。在这篇综述中，我们将总结来自神经炎症性疾病研究的关于MDSCs的数据及其在多发性硬化症中的潜在作用，以便介绍这种极具前景的细胞类型在未来基于细胞的治疗中的假定用途。本文是由Helga E. de Vries和Markus Schwaninger编辑的名为《神经炎症》的特刊的一部分。
