Suzuki Daniela O H, Marques Claudia M G, Rangel Marcelo M M
Institute of Biomedical Engineering, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil.
Center for Health Sciences and Sports, State University of Santa Catarina (UDESC), Florianópolis, Santa Catarina, Brazil.
Artif Organs. 2016 Jul;40(7):705-11. doi: 10.1111/aor.12631. Epub 2015 Nov 3.
The combination of chemotherapy drugs and high electric field treatment in local cancer is named electrochemotherapy. The European Standard Operation Procedure of Electrochemotherapy (ESOPE) provides guidelines for treatment of cutaneous and subcutaneous tumors. The electrochemotherapy of numerous tumors varying in sizes is more convenient using needle electrodes. However, ESOPE recommends that needle electrodes are applied to deeper tumors. The application of needle electrodes to treatment of superficial small tumors seems to be practical in electrochemotherapy. Plate electrodes and gel improve the electrochemotherapy efficacy. This technique provides electric field homogeneity in irregularly shaped tissue structures (bulk tumors). We propose an investigation of needle electrode and gel in electrochemotherapy of superficial tumors. In vivo experiment with squamous cell carcinoma (SCC) spontaneous nodules in dog was used to validate the mathematical tissue model. The numerical model considers the tissue conductivity dependent on local electric field. Our studies demonstrated that conductive gel is important for effective treatment of superficial tumors with needle electrodes. The needle electrodes and gel presented reduction of medium current, increased the tumor-free margin, and improved the practical application in relation to plate electrode.
化疗药物与高电场治疗相结合用于局部癌症被称为电化学疗法。欧洲电化学疗法标准操作程序（ESOPE）为皮肤和皮下肿瘤的治疗提供了指导方针。使用针电极对大小各异的众多肿瘤进行电化学疗法更为便捷。然而，ESOPE建议将针电极应用于较深的肿瘤。在电化学疗法中，将针电极应用于浅表小肿瘤的治疗似乎切实可行。平板电极和凝胶可提高电化学疗法的疗效。该技术在不规则形状的组织结构（实体肿瘤）中提供电场均匀性。我们提议对针电极和凝胶在浅表肿瘤电化学疗法中的应用进行研究。利用犬鳞状细胞癌（SCC）自发结节进行体内实验以验证数学组织模型。该数值模型考虑了依赖于局部电场的组织电导率。我们的研究表明，导电凝胶对于使用针电极有效治疗浅表肿瘤至关重要。针电极和凝胶可降低中等电流，增加无瘤边缘，并改善相对于平板电极的实际应用。
