Suzuki Daniela O H, Berkenbrock José A, de Oliveira Krishna D, Freytag Jennifer O, Rangel Marcelo M M
Institute of Biomedical Engineering, Federal University of Santa Catarina (UFSC), Florianópolis-SC.
Oncology Veterinary, VetCâncer, São Paulo-SP, Brazil.
Artif Organs. 2017 Aug;41(8):767-773. doi: 10.1111/aor.12858. Epub 2016 Dec 27.
Electrochemotherapy is a new modality of local cancer treatment that increases the delivery of chemotherapy drugs into tumor cells by applying intense electric fields. This novel electrochemotherapy application was applied as an adjuvant to surgery and eliminated intranasal tumors in dog. The treatment challenges are the surgery limitations due to anatomy and residual tumor in the bone cavity. Most of the tumoral mass on nasal cavity was surgically removed. The internal nasal cavity was immersed in liquid and bleomycin before applying electric field. The solution was necessary to increase the superficial contact between plate electrodes and residual tumor. The numerical study demonstrated electrochemotherapy efficiency in different clinical situations. The proximity between electrodes and bone (<3 mm) and bone irregularities affect the electric field distribution on tumoral tissue. The tumoral tissue around bone protuberances tends to be eliminated. Electrochemotherapy with plate electrodes inside the cavity might not be effective. Different values of electric conductivity solution were studied; the ideal value was 0.5 S/m. The numerical and experimental results confirm the successful application of electrochemotherapy on dog nasal cavity.
电化学疗法是一种局部癌症治疗的新方法，通过施加强电场增加化疗药物向肿瘤细胞内的递送。这种新型的电化学疗法被用作手术辅助手段，并消除了犬的鼻内肿瘤。治疗面临的挑战是由于解剖结构导致的手术局限性以及骨腔内的残留肿瘤。鼻腔内的大部分肿瘤团块已通过手术切除。在施加电场之前，将鼻腔内部浸入液体和博来霉素中。该溶液对于增加平板电极与残留肿瘤之间的表面接触是必要的。数值研究表明了电化学疗法在不同临床情况下的效果。电极与骨骼之间的距离（<3毫米）以及骨骼不规则性会影响肿瘤组织上的电场分布。骨隆起周围的肿瘤组织往往会被消除。在腔内使用平板电极进行电化学疗法可能无效。研究了不同电导率溶液的值；理想值为0.5 S/m。数值和实验结果证实了电化学疗法在犬鼻腔上的成功应用。
