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光感受器盘形态发生：经典的内陷模型占主导地位。

Photoreceptor disc morphogenesis: The classical evagination model prevails.

作者信息

Pugh Edward N

机构信息

Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, Davis, CA 95616 Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, Davis, CA 95616

出版信息

J Cell Biol. 2015 Nov 9;211(3):491-3. doi: 10.1083/jcb.201510067. Epub 2015 Nov 2.

DOI:10.1083/jcb.201510067
PMID:26527745
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4639855/
Abstract

Vision begins in photoreceptor outer segments with light captured by opsins in continually synthesized disc membranes. The process by which rod photoreceptor discs are formed has been controversial. In this issue, Ding et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201508093) show conclusively that rod discs are formed by plasma membrane evagination.

摘要

视觉始于光感受器的外段，光被不断合成的盘状膜中的视蛋白捕获。视杆光感受器盘的形成过程一直存在争议。在本期杂志中，丁等人（2015年。《细胞生物学杂志》。http://dx.doi.org/10.1083/jcb.201508093）确凿地表明，视杆盘是由质膜内陷形成的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64be/4639855/f7289bcf80f2/JCB_201510067_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64be/4639855/f7289bcf80f2/JCB_201510067_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64be/4639855/f7289bcf80f2/JCB_201510067_Fig1.jpg

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本文引用的文献

1
Discs of mammalian rod photoreceptors form through the membrane evagination mechanism.哺乳动物视杆光感受器的圆盘是通过膜内陷机制形成的。
J Cell Biol. 2015 Nov 9;211(3):495-502. doi: 10.1083/jcb.201508093. Epub 2015 Nov 2.
2
Ultrastructural visualization of trans-ciliary rhodopsin cargoes in mammalian rods.哺乳动物视杆细胞中跨睫状体视紫红质货物的超微结构可视化。
Cilia. 2015 Feb 8;4:4. doi: 10.1186/s13630-015-0013-1. eCollection 2015.
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From central to rudimentary to primary: the history of an underappreciated organelle whose time has come. The primary cilium.
Cold Spring Harb Perspect Biol. 2017 Oct 3;9(10):a028274. doi: 10.1101/cshperspect.a028274.
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Molecular basis for photoreceptor outer segment architecture.光感受器外段结构的分子基础。
Prog Retin Eye Res. 2016 Nov;55:52-81. doi: 10.1016/j.preteyeres.2016.05.003. Epub 2016 Jun 1.
从中心体到基体再到初级纤毛：一个长期被忽视的细胞器迎来了属于它的时代。初级纤毛。
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4
SARA-regulated vesicular targeting underlies formation of the light-sensing organelle in mammalian rods.SARA调节的囊泡靶向作用是哺乳动物视杆细胞中光感受细胞器形成的基础。
Cell. 2007 Aug 10;130(3):535-47. doi: 10.1016/j.cell.2007.06.030.
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Role of peripherin/rds in vertebrate photoreceptor architecture and inherited retinal degenerations.外周蛋白/视网膜变性慢病毒（peripherin/rds）在脊椎动物光感受器结构及遗传性视网膜变性中的作用
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6
Disc morphogenesis in vertebrate photoreceptors.脊椎动物光感受器中的视盘形态发生。
J Comp Neurol. 1980 Apr 1;190(3):501-8. doi: 10.1002/cne.901900307.
7
The renewal of photoreceptor cell outer segments.光感受器细胞外节的更新。
J Cell Biol. 1967 Apr;33(1):61-72. doi: 10.1083/jcb.33.1.61.
8
Localization of peripherin/rds in the disk membranes of cone and rod photoreceptors: relationship to disk membrane morphogenesis and retinal degeneration.外周蛋白/视网膜变性慢病毒（peripherin/rds）在视锥和视杆光感受器盘膜中的定位：与盘膜形态发生和视网膜变性的关系。
J Cell Biol. 1992 Feb;116(3):659-67. doi: 10.1083/jcb.116.3.659.
9
Rods and cones in the mouse retina. I. Structural analysis using light and electron microscopy.小鼠视网膜中的视杆细胞和视锥细胞。I. 利用光学显微镜和电子显微镜进行的结构分析。
J Comp Neurol. 1979 Nov 15;188(2):245-62. doi: 10.1002/cne.901880204.
10
Procion yellow: a marker dye for outer segment disc patency and for rod renewal.普施安黄：一种用于外段盘膜通畅性和视杆细胞更新的标记染料。
Exp Eye Res. 1976 Aug;23(2):139-48. doi: 10.1016/0014-4835(76)90197-4.