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Can the duration of tuberculosis treatment be shortened with higher dosages of rifampicin?

作者信息

Dutta Noton K, Karakousis Petros C

机构信息

Department of Medicine, Center for Tuberculosis Research, Johns Hopkins University School of Medicine Baltimore, MD, USA.

Department of Medicine, Center for Tuberculosis Research, Johns Hopkins University School of Medicine Baltimore, MD, USA ; Department of International Health, Johns Hopkins Bloomberg School of Public Health Baltimore, MD, USA.

出版信息

Front Microbiol. 2015 Oct 14;6:1117. doi: 10.3389/fmicb.2015.01117. eCollection 2015.

DOI:10.3389/fmicb.2015.01117
PMID:26528265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4604300/
Abstract
摘要

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Can the duration of tuberculosis treatment be shortened with higher dosages of rifampicin?增加利福平剂量能否缩短结核病的治疗疗程？
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High-dose rifampicin kills persisters, shortens treatment duration, and reduces relapse rate in vitro and in vivo.高剂量利福平可杀死持留菌，缩短治疗时间，并降低体内外的复发率。
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Statin adjunctive therapy shortens the duration of TB treatment in mice.他汀类辅助治疗可缩短小鼠结核病治疗疗程。
J Antimicrob Chemother. 2016 Jun;71(6):1570-7. doi: 10.1093/jac/dkw014. Epub 2016 Feb 21.

本文引用的文献

1
High-dose rifampicin kills persisters, shortens treatment duration, and reduces relapse rate in vitro and in vivo.高剂量利福平可杀死持留菌，缩短治疗时间，并降低体内外的复发率。
Front Microbiol. 2015 Jun 23;6:641. doi: 10.3389/fmicb.2015.00641. eCollection 2015.
2
Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses.结核病病理学、微环境及治疗反应的异质性
Immunol Rev. 2015 Mar;264(1):288-307. doi: 10.1111/imr.12252.
3
Study of efflux pump gene expression in rifampicin-monoresistant Mycobacterium tuberculosis clinical isolates.利福平单耐药结核分枝杆菌临床分离株中外排泵基因表达的研究。
J Antibiot (Tokyo). 2015 Jul;68(7):431-5. doi: 10.1038/ja.2015.9. Epub 2015 Feb 18.
4
A dose-ranging trial to optimize the dose of rifampin in the treatment of tuberculosis.一项优化利福平剂量治疗结核病的剂量范围试验。
Am J Respir Crit Care Med. 2015 May 1;191(9):1058-65. doi: 10.1164/rccm.201407-1264OC.
5
Rifampicin and rifapentine significantly reduce concentrations of bedaquiline, a new anti-TB drug.利福平与利福喷汀可显著降低新型抗结核药物贝达喹啉的血药浓度。
J Antimicrob Chemother. 2015 Apr;70(4):1106-14. doi: 10.1093/jac/dku504. Epub 2014 Dec 21.
6
Could high-concentration rifampicin kill rifampicin-resistant M. tuberculosis? Rifampicin MIC test in rifampicin-resistant isolates from patients with osteoarticular tuberculosis.高浓度利福平能否杀死耐利福平的结核分枝杆菌？骨与关节结核患者耐利福平分离株的利福平MIC检测。
J Orthop Surg Res. 2014 Dec 3;9:124. doi: 10.1186/s13018-014-0124-1.
7
Four-month moxifloxacin-based regimens for drug-sensitive tuberculosis.基于莫西沙星的四个月疗程用于治疗药物敏感型肺结核。
N Engl J Med. 2014 Oct 23;371(17):1577-87. doi: 10.1056/NEJMoa1407426. Epub 2014 Sep 7.
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Antimicrob Agents Chemother. 2014 Jun;58(6):3035-42. doi: 10.1128/AAC.01918-13. Epub 2014 Mar 10.
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J Infect Dis. 2013 Nov 1;208(9):1464-73. doi: 10.1093/infdis/jit352. Epub 2013 Jul 29.
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Am J Respir Crit Care Med. 2013 May 15;187(10):1127-34. doi: 10.1164/rccm.201207-1210OC.