Senhaji Nezha, Kojok Kevin, Darif Youssef, Fadainia Christophe, Zaid Younes
Laboratory of Genetic and Molecular Pathology (LGPM), Medical School, Hassan II University , Casablanca , Morocco.
Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute , Montreal, QC , Canada.
Front Immunol. 2015 Oct 16;6:529. doi: 10.3389/fimmu.2015.00529. eCollection 2015.
Inflammatory bowel disease (IBD) is a chronic and multifactorial disease of the gastrointestinal tract. The exact etiology of IBD remains complex and unclear involving an inadequately defined relationship between microbial insult, genetic predisposition, altered intestinal barrier permeability, oxidative stress components and abnormal immune responses. The role of the co-stimulatory system made up of cluster of differentiation 40 protein (CD40) and its ligand (CD40L) in the response of the immune system to pathogens is now widely accepted. The implication of CD40/CD40L axis in immune system disorders due to its important role as signal transduction pathway among immune cells is well documented. Several studies have suggested that CD40/CD40L interactions regulate oxidative stress; this can affect various signaling pathways leading to IBD development. Hence, CD40/CD40L signaling pathway may become a new target for IBD treatment. This review will cover the general contribution of the CD40/CD40L dyad in the development of IBD in order to facilitate future approaches aiming to elucidate the immunological mechanisms that control gut inflammation.
炎症性肠病（IBD）是一种胃肠道的慢性多因素疾病。IBD的确切病因仍然复杂且不明，涉及微生物侵害、遗传易感性、肠道屏障通透性改变、氧化应激成分和异常免疫反应之间定义不充分的关系。由分化簇40蛋白（CD40）及其配体（CD40L）组成的共刺激系统在免疫系统对病原体的反应中的作用现已被广泛接受。CD40/CD40L轴因其在免疫细胞间作为信号转导途径的重要作用而在免疫系统疾病中的影响已有充分记录。多项研究表明，CD40/CD40L相互作用调节氧化应激；这会影响导致IBD发生的各种信号通路。因此，CD40/CD40L信号通路可能成为IBD治疗的新靶点。本综述将涵盖CD40/CD40L二元组在IBD发生中的总体作用，以便为未来旨在阐明控制肠道炎症的免疫机制的研究方法提供便利。
