Yilmaz Mehmet, Delibas Ilhan Bahri, Isaoglu Unal, Ingec Metin, Borekci Bunyamin, Ulug Pasa
Obstetrics and Gynecology Department, Ataturk University, Erzurum, Turkey.
Nene Hatun Obstetrics and Gynecology Hospital, Erzurum, Turkey.
Arch Med Sci. 2015 Oct 12;11(5):989-93. doi: 10.5114/aoms.2013.40095.
The aim of the study was to examine the relationship between mean platelet volume (MPV) and recurrent miscarriage in order to illuminate the etiopathogenesis of recurrent miscarriage.
We retrospectively investigated the data of 120 patients with unexplained recurrent miscarriage (group 1), and compared them with the data of 120 match-paired patients in the control group (group 2). The definition of recurrent miscarriage was accepted as two or more failed clinical pregnancies which were documented by ultrasonography or histopathologic examination. All patients in the recurrent miscarriage group were evaluated with diagnostic tests for the etiology of recurrent miscarriage. Total blood count parameters, including hemoglobin, mean corpuscular volume, red cell distribution width, white blood cells, platelets, and mean platelet volume, were compared.
The average patient age at the time of examination was 29.07 ±2.81 years in group I and 28.53 ±3.5 years in group II (p > 0.05). Mean body mass index (BMI) was similar between group 1 and group 2, 22.54 ±3.17 and 22.99 ±2.38, respectively (p > 0.05). Mean hemoglobin, mean corpuscular volume, red cell distribution width, and white blood cell and platelet levels were similar in both groups (p > 0.05). Mean platelet volume levels were significantly higher in group I (9.45 ±1.09 fl) than in group II (7.63 ±0.52 fl) (p = 0.001).
Higher MPV values in the study group suggest and support the importance of thromboembolic events in the etiology of recurrent miscarriage.
本研究旨在探讨平均血小板体积（MPV）与复发性流产之间的关系，以阐明复发性流产的病因发病机制。
我们回顾性调查了120例不明原因复发性流产患者的数据（第1组），并将其与对照组120例匹配的患者数据（第2组）进行比较。复发性流产的定义为经超声检查或组织病理学检查证实的两次或更多次临床妊娠失败。复发性流产组的所有患者均接受了复发性流产病因的诊断测试。比较了全血细胞计数参数，包括血红蛋白、平均红细胞体积、红细胞分布宽度、白细胞、血小板和平均血小板体积。
第1组检查时患者的平均年龄为29.07±2.81岁，第2组为28.53±3.5岁（p>0.05）。第1组和第2组的平均体重指数（BMI）相似，分别为22.54±3.17和22.99±2.38（p>0.05）。两组的平均血红蛋白、平均红细胞体积、红细胞分布宽度以及白细胞和血小板水平相似（p>0.05）。第1组的平均血小板体积水平（9.45±1.09 fl）显著高于第2组（7.63±0.52 fl）（p = 0.001）。
研究组中较高的MPV值提示并支持血栓栓塞事件在复发性流产病因中的重要性。
