Pilipchuk N S, Kliachkin L M, Protsiuk R G
Vopr Kurortol Fizioter Lech Fiz Kult. 1989 Jan-Feb(1):21-4.
Basing on the literature and original data, the authors discuss specific features of a local and resorptive action of inhaled chemotherapeutic aerosols, provide evidence for advantages of the drugs inhalation over their introduction extrapulmonarily for treatment of respiration pathology. The data are presented on potential damage of aerosols to mucociliary clearance, air-blood barrier, surfactant system. Ways of these adverse effects correction are outlined. The authors hold that inhalations used for drug resorption should not be recommended for wide application until the drugs are tested for toxicity and relevant pharmacokinetics is studied.
基于文献和原始数据，作者讨论了吸入性化疗气雾剂的局部和吸收作用的具体特征，为药物吸入治疗呼吸疾病优于经肺外给药提供了证据。文中介绍了气雾剂对黏液纤毛清除、气血屏障、表面活性物质系统的潜在损害。概述了纠正这些不良反应的方法。作者认为，在对药物进行毒性测试并研究相关药代动力学之前，不应推荐用于药物吸收的吸入疗法广泛应用。
