Chu I, Villeneuve D C, Secours V, Franklin C, Rock G, Viau A
Drug Metab Dispos. 1978 Mar-Apr;6(2):146-9.
The absorption, distribution and metabolic excretion of mono-2-ethylhexyl [7-14C]phthalate (MEHP) were studied in the rat. This compound was readily absorbed from the gastrointestinal tract. Radioactivity following intravenous administration of 14C-MEHP was rapidly distributed in all tissues, with the highest levels occurring in the liver, kidney, and urinary bladder. Excretion of radioactivity was rapid and approximately 80% of the dose was eliminated 24 hr after oral administration, 72% in the urine and 8% in feces. MEHP was extensively metabolized after oral administration, and the major urinary metabolites were identified as an alcohol, a ketone, and an acid resulting from the side-chain oxidation of MEHP. A trace of o-phthalic acid was also identified.
研究了大鼠体内单-2-乙基己基[7-¹⁴C]邻苯二甲酸酯（MEHP）的吸收、分布及代谢排泄情况。该化合物很容易从胃肠道吸收。静脉注射¹⁴C-MEHP后，放射性迅速分布于所有组织，肝脏、肾脏和膀胱中的含量最高。放射性排泄迅速，口服给药后24小时约80%的剂量被消除，72%经尿液排出，8%经粪便排出。口服给药后MEHP被广泛代谢，主要尿代谢产物被鉴定为一种醇、一种酮和一种由MEHP侧链氧化产生的酸。还鉴定出微量邻苯二甲酸。
