Pizarro Fernando, Olivares Manuel, Maciero Eugenia, Krasnoff Gustavo, Cócaro Nicolas, Gaitan Diego
Micronutrients Laboratory, Institute of Nutrition and Food Technology (INTA), University of Chile, Avda, El Líbano 5524, 6903625 Santiago, Chile.
Kasdorf S.A. Av. Panamericana y Gral. Savio (1619) Garín, Buenos Aires, Argentina.
Nutrients. 2015 Oct 30;7(11):8952-9. doi: 10.3390/nu7115448.
Fortification of milk formulas with iron is a strategy widely used, but the absorption of non-heme iron is low. The purpose of this study was to measure the bioavailability of two iron fortified milk formulas designed to cover toddlers´ nutritional needs. These milks were fortified with iron sulfate stabilized with maltodextrin and citric acid.
15 women (33-47 years old) participated in study. They received on different days, after an overnight fast, 200 mL of Formula A; 200 mL of Formula B; 30 mL of a solution of iron and ascorbic acid as reference dose and 200 mL of full fat cow's milk fortified with iron as ferrous sulfate. Milk formulas and reference dose were labeled with radioisotopes (59)Fe or (55)Fe, and the absorption of iron measured by erythrocyte incorporation of radioactive Fe.
The geometric mean iron absorption corrected to 40% of the reference dose was 20.6% for Formula A and 20.7% for Formula B, versus 7.5% of iron fortified cow's milk (p < 0.001). The post hoc Sheffé indeed differences between the milk formulas and the cow's milk (p < 0.001).
Formulas A and B contain highly bioavailable iron, which contributes to covering toddlers´ requirements of this micronutrient.
在婴儿配方奶粉中强化铁是一种广泛应用的策略，但非血红素铁的吸收较低。本研究的目的是测定两种旨在满足幼儿营养需求的铁强化婴儿配方奶粉的生物利用度。这些奶粉用麦芽糊精和柠檬酸稳定的硫酸亚铁进行强化。
15名女性（33 - 47岁）参与了研究。她们在不同日期，经过一夜禁食后，分别摄入200毫升配方奶粉A；200毫升配方奶粉B；30毫升铁与抗坏血酸的溶液作为参考剂量，以及200毫升用硫酸亚铁强化铁的全脂牛奶。婴儿配方奶粉和参考剂量用放射性同位素（59）Fe或（55）Fe进行标记，并通过红细胞对放射性Fe的摄取来测量铁的吸收。
校正至参考剂量40%的几何平均铁吸收率，配方奶粉A为20.6%，配方奶粉B为20.7%，而铁强化牛奶为7.5%（p < 0.001）。事后谢费检验显示婴儿配方奶粉和牛奶之间确实存在差异（p < 0.001）。
配方奶粉A和B含有生物利用度高的铁，有助于满足幼儿对这种微量营养素的需求。
