Hilton Thomas F, Pilkonis Paul A
Martesia Way, Indian Harbour Beach, FL 32937, USA.
Western Psychiatric Institute & Clinic, University of Pittsburgh Medical Center, 3811 O'Hara Street Pittsburgh, PA 15213, USA.
Behav Sci (Basel). 2015 Oct 30;5(4):477-95. doi: 10.3390/bs5040477.
Modern health services now strive for individualized treatment. This approach has been enabled by the increase in knowledge derived from neuroscience and genomics. Substance use disorders are no exception to individualized treatment even though there are no gene-specific medications yet available. What is available is the ability to quickly and precisely assess and monitor biopsychosocial variables known to vary during addiction recovery and which place addicts at increased risk of relapse. Monitoring a broad spectrum of biopsychosocial health enables providers to address diverse genome-specific changes that might trigger withdrawal from treatment or recovery relapse in time to prevent that from occurring. This paper describes modern measurement tools contained in the NIH Patient-Reported Outcomes Measurement Information System (PROMIS) and the NIH Toolbox and suggests how they might be applied to support recovery from alcohol and other substance use disorders in both pharmacological and abstinence-oriented modalities of care.
现代医疗服务如今致力于个性化治疗。神经科学和基因组学知识的增长使得这种方法得以实现。物质使用障碍也不例外，尽管目前还没有针对特定基因的药物，但仍可采用个性化治疗。现有的能力是能够快速、精确地评估和监测已知在成瘾康复过程中会发生变化且会增加成瘾者复发风险的生物心理社会变量。监测广泛的生物心理社会健康状况使医疗服务提供者能够及时应对各种可能引发治疗中断或康复复发的特定基因组变化，从而预防此类情况的发生。本文介绍了美国国立卫生研究院患者报告结局测量信息系统（PROMIS）和美国国立卫生研究院工具包中包含的现代测量工具，并提出了如何将它们应用于支持酒精及其他物质使用障碍患者在药物治疗和以戒酒为导向的护理模式下实现康复。
