双酚A在雄性和雌性沙鼠的新生儿前列腺发育过程中促进抗增殖作用。
Bisphenol-A promotes antiproliferative effects during neonatal prostate development in male and female gerbils.
作者信息
de Lima Rodrigo Fernandes, Rodriguez Daniel Andrés Osório, Campos Mônica Souza, Biancardi Manoel Francisco, dos Santos Iana Figueiredo Ferreira Roriz, de Oliveira Wendyson Duarte, Cavasin Gláucia Maria, Marques Mara Rubia, Taboga Sebastião Roberto, Santos Fernanda Cristina Alcantara
机构信息
Department of Histology, Embryology and Cell Biology, Federal University of Goiás, Samambaia II, Goiânia, Goiás 74001970, Brazil.
São Paulo State University - UNESP, Department of Biology, Laboratory of Microscopy and Microanalysis, Rua Cristóvão Colombo, 2265, São José do Rio Preto, São Paulo 15054000, Brazil.
出版信息
Reprod Toxicol. 2015 Dec;58:238-45. doi: 10.1016/j.reprotox.2015.10.016. Epub 2015 Oct 31.
The aim of this study was to evaluate the development of male and female neonatal gerbil prostate under normal conditions and exposed to bisphenol-A (BPA). Normal postnatal development of the female gerbil prostate occurs earlier than and is morphologically distinct from that occurring in males. In BPA-exposed PND8 gerbils, we have not observed evidence of alterations in the ductal branching in either gender. However, the exposure to BPA alters the immunolabeling pattern of AR, ERα, and PCNA. In males, the exposure to high dosages of BPA resulted in a decrease in the proliferative status of the developing ventral prostate. In females, both high and low dosages were sufficient to decrease the proliferation of paraurethral buds in the branching process by more than 50%. Therefore, the obtained data indicate that BPA promotes antiproliferative effects during the neonatal development of the gerbil prostate, with more sensitivity to this endocrine disruptor in females.
本研究的目的是评估正常条件下以及暴露于双酚A（BPA）的雄性和雌性新生沙鼠前列腺的发育情况。雌性沙鼠前列腺的正常产后发育比雄性更早发生，且在形态上与雄性不同。在暴露于BPA的出生后第8天（PND8）的沙鼠中，我们未观察到任何一种性别的导管分支有改变的迹象。然而，暴露于BPA会改变雄激素受体（AR）、雌激素受体α（ERα）和增殖细胞核抗原（PCNA）的免疫标记模式。在雄性中，暴露于高剂量的BPA导致发育中的腹侧前列腺增殖状态下降。在雌性中，高剂量和低剂量都足以使尿道旁芽在分支过程中的增殖减少超过50%。因此，所获得的数据表明，BPA在沙鼠前列腺的新生发育过程中促进抗增殖作用，雌性对这种内分泌干扰物更为敏感。
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