Gao Qiang, Shao Dan, Pan Aizhen, Gao Mingyong, Liu Zaiyi, Liang Changhong
aSouthern Medical University bDepartment of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou cDepartment of Radiology, The First People's Hospital of Foshan City, Foshan, Guangdong, People's Republic of China.
Eur J Gastroenterol Hepatol. 2016 Jan;28(1):70-3. doi: 10.1097/MEG.0000000000000500.
Transient elastography is a noninvasive and reliable method for the assessment of liver stiffness. This study aimed to assess liver stiffness of asymptomatic liver fluke disease patients by FibroScan and evaluate the factors influencing liver stiffness.
Overall, 65 patients were prospectively recruited from The First People's Hospital of Foshan, Guangdong, China. All patients were diagnosed with liver fluke disease; their durations of ingested freshwater raw fish or shrimp were more than 10 years, and none of them had abnormal liver function and hepatitis B virus or hepatitis C virus infection, or clinical symptoms. All patients underwent FibroScan, blood biochemical examination, and BMI measurement on the same day. Liver stiffness measurement (LSM) values, sex, age, durations of ingested freshwater raw fish or shrimp, and BMI were recorded. LSM value greater than 7.4 kPa was defined as abnormal.
A total of 27 patients (41.5%) had abnormal LSM values. On partial correlation analysis, duration of ingested freshwater raw fish or shrimp was the independent factor that showed a positive correlation with abnormal LSM values (r=0.502, P=0.012). An independent-samples t-test showed that the durations of patients with abnormal LSM values were significantly longer than the durations of patients with normal LSM values (P<0.001). Sex, age, and BMI were not significantly correlated with LSM values (P>0.05).
A high proportion of asymptomatic liver fluke disease patients had abnormal LSM values. The durations of patients with abnormal LSM values were significantly longer than the durations of patients with normal LSM values and the durations of patients with abnormal LSM values were an independent factor that showed a positive correlation with abnormal LSM values.
瞬时弹性成像技术是一种用于评估肝脏硬度的非侵入性可靠方法。本研究旨在通过FibroScan评估无症状肝吸虫病患者的肝脏硬度，并评估影响肝脏硬度的因素。
总共从中国广东佛山第一人民医院前瞻性招募了65例患者。所有患者均被诊断为肝吸虫病；他们食用淡水生鱼或虾的时间超过10年，且均无肝功能异常、乙型肝炎病毒或丙型肝炎病毒感染，也无临床症状。所有患者于同一天接受FibroScan检查、血液生化检查及体重指数（BMI）测量。记录肝脏硬度值（LSM）、性别、年龄、食用淡水生鱼或虾的时间以及BMI。LSM值大于7.4 kPa被定义为异常。
共有27例患者（41.5%）LSM值异常。偏相关分析显示，食用淡水生鱼或虾的时间是与LSM值异常呈正相关的独立因素（r = 0.502，P = 0.012）。独立样本t检验显示，LSM值异常患者的食用时间显著长于LSM值正常患者的食用时间（P < 0.001）。性别、年龄和BMI与LSM值无显著相关性（P > 0.05）。
高比例的无症状肝吸虫病患者LSM值异常。LSM值异常患者的食用时间显著长于LSM值正常患者的食用时间，且LSM值异常患者的食用时间是与LSM值异常呈正相关的独立因素。
