Štillová Klára, Jurák Pavel, Chládek Jan, Chrastina Jan, Halámek Josef, Bočková Martina, Goldemundová Sabina, Říha Ivo, Rektor Ivan
Central European Institute of Technology CEITEC, Brain and Mind Research Program, Brno, Czech Republic; Department of Neurology, St. Anne´s Teaching Hospital, Medical School of Masaryk University, Brno, Czech Republic.
Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno, Czech Republic.
PLoS One. 2015 Nov 3;10(11):e0140778. doi: 10.1371/journal.pone.0140778. eCollection 2015.
To study the involvement of the anterior nuclei of the thalamus (ANT) as compared to the involvement of the hippocampus in the processes of encoding and recognition during visual and verbal memory tasks.
We studied intracerebral recordings in patients with pharmacoresistent epilepsy who underwent deep brain stimulation (DBS) of the ANT with depth electrodes implanted bilaterally in the ANT and compared the results with epilepsy surgery candidates with depth electrodes implanted bilaterally in the hippocampus. We recorded the event-related potentials (ERPs) elicited by the visual and verbal memory encoding and recognition tasks.
P300-like potentials were recorded in the hippocampus by visual and verbal memory encoding and recognition tasks and in the ANT by the visual encoding and visual and verbal recognition tasks. No significant ERPs were recorded during the verbal encoding task in the ANT. In the visual and verbal recognition tasks, the P300-like potentials in the ANT preceded the P300-like potentials in the hippocampus.
The ANT is a structure in the memory pathway that processes memory information before the hippocampus. We suggest that the ANT has a specific role in memory processes, especially memory recognition, and that memory disturbance should be considered in patients with ANT-DBS and in patients with ANT lesions. ANT is well positioned to serve as a subcortical gate for memory processing in cortical structures.
研究丘脑前核（ANT）与海马体在视觉和言语记忆任务的编码和识别过程中的参与情况，并进行比较。
我们对药物难治性癫痫患者进行了脑内记录，这些患者接受了ANT的深部脑刺激（DBS），通过双侧植入ANT的深度电极进行记录，并将结果与双侧海马体植入深度电极的癫痫手术候选者进行比较。我们记录了视觉和言语记忆编码及识别任务引发的事件相关电位（ERP）。
在视觉和言语记忆编码及识别任务中，海马体记录到了类似P300的电位，在视觉编码以及视觉和言语识别任务中，ANT记录到了类似P300的电位。在ANT的言语编码任务期间未记录到明显的ERP。在视觉和言语识别任务中，ANT中的类似P300的电位先于海马体中的类似P300的电位出现。
ANT是记忆通路中的一个结构，在海马体之前处理记忆信息。我们认为ANT在记忆过程中，特别是在记忆识别方面具有特定作用，并且对于接受ANT-DBS的患者和患有ANT病变的患者，应考虑记忆障碍。ANT处于良好位置，可作为皮质结构中记忆处理的皮质下闸门。
