Kinoshita Yuka
Nihon Rinsho. 2015 Oct;73(10):1728-32.
Secondary osteoporosis is a bone disease characterized by decreased bone mass that predisposes fractures due to underlying disorders or medication. Disorders of the endocrine system, such as primary hyperparathyroidism, hyperthyroidism, hypogonadism, growth hormone deficiency, Cushing's syndrome, and anorexia nervosa frequently cause secondary osteoporosis. In those diseases, hormone excess or deficiency affects functions of osteoblasts, osteocyte, and osteoclasts, leading to aberrant bone remodeling. Bisphosphonates are the first-choice pharmacological agents for fracture prevention in most patients with secondary osteoporosis along with treatment of the underlying disease.
继发性骨质疏松是一种以骨量减少为特征的骨病，由于潜在疾病或药物治疗而易发生骨折。内分泌系统疾病，如原发性甲状旁腺功能亢进、甲状腺功能亢进、性腺功能减退、生长激素缺乏、库欣综合征和神经性厌食症，常导致继发性骨质疏松。在这些疾病中，激素过多或缺乏会影响成骨细胞、骨细胞和破骨细胞的功能，导致异常的骨重塑。双膦酸盐是大多数继发性骨质疏松患者预防骨折的首选药物，同时也是治疗潜在疾病的药物。
