Geborek P, Forslind K, Wollheim F A
Department of Rheumatology, University Hospital of Lund, Sweden.
Ann Rheum Dis. 1989 Apr;48(4):281-6. doi: 10.1136/ard.48.4.281.
A method for measuring synovial blood flow changes using the laser Doppler technique is described. Mean blood flow and mean pulse amplitude decreased by 50-70% in relation to the reference level when the intra-articular hydrostatic pressure in effusive knee joints of patients with rheumatoid arthritis was increased. As an increase of intra-articular pressure of as little as 20 mmHg decreased synovial blood flow significantly it is suggested that hypoxia may occur in vivo during joint use in the presence of an effusion. This may be of aetiopathogenetic importance for tissue destruction and the persistence of chronic synovitis.
本文描述了一种使用激光多普勒技术测量滑膜血流变化的方法。类风湿性关节炎患者膝关节积液时，关节内静水压升高，平均血流和平均脉搏幅度相对于参考水平降低了50-70%。由于关节内压力仅增加20 mmHg就会显著降低滑膜血流，因此提示在存在积液的情况下，关节使用过程中体内可能会发生缺氧。这可能对组织破坏和慢性滑膜炎的持续存在具有病因学重要性。
