Dawood M Y
Department of Obstetrics and Gynecology, University of Illinois College of Medicine, Chicago 60612.
Am J Perinatol. 1989 Apr;6(2):167-72. doi: 10.1055/s-2007-999569.
Based on findings of maternal and fetal circulating oxytocin levels during spontaneous labor and the available information on oxytocin secretion patterns, the dosage and mode of administration of oxytocin for induction of labor is discussed. It is recommended that intravenous infusion rates should not exceed 2 to 8 mU/min. Oxytocin administered in a pulsatile fashion beginning with 1 mU/min every 8 minutes with doubling the pulse dose every 24 minutes is equally as efficient as continuous infusion. Because both the peak levels and the total dose of oxytocin needed for induction are lower with pulsatile than continuous administration, the risk of adverse effects for the mother and the fetus is significantly reduced.
基于自然分娩过程中母体和胎儿循环中催产素水平的研究结果以及关于催产素分泌模式的现有信息，讨论了用于引产的催产素的剂量和给药方式。建议静脉输注速率不应超过2至8 mU/分钟。以脉冲方式给药的催产素，起始剂量为每分钟1 mU，每8分钟给药一次，每24分钟将脉冲剂量加倍，其效果与持续输注相同。由于脉冲给药诱导所需的催产素峰值水平和总剂量均低于持续给药，因此母亲和胎儿出现不良反应的风险显著降低。
