Daya S
Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada.
Br J Obstet Gynaecol. 1989 Mar;96(3):275-80. doi: 10.1111/j.1471-0528.1989.tb02386.x.
Progesterone appears to be necessary to support an early pregnancy, and it has been used for this purpose for several decades. Its potential role in women with recurrent miscarriage due to luteal phase deficiency has been suggested, but its efficacy has not yet been demonstrated. Three controlled trials of progesterone treatment in women with recurrent miscarriage have shown small, but not statistically significant, increases in the rates of pregnancies that continue beyond 20 weeks in the treated groups. None of these studies had sufficient statistical power to detect a clinically significant improvement in outcome but pooling the results of these studies using the principles of meta-analysis has allowed an overall effect of treatment to be calculated. The resulting odds ratio for pregnancies reaching at least 20 weeks gestation was 3.09 (95% CI 1.28 to 7.42) which indicates that there is evidence to support the suggestion that progesterone given in early pregnancy is useful in women with recurrent miscarriage. Although, before progesterone is used in this way its efficacy in women with recurrent miscarriage due to luteal phase deficiency must be assessed in prospective double-blind randomized controlled trials mounted in the light of the results of this meta-analysis.
孕酮似乎是维持早期妊娠所必需的，并且已经用于此目的数十年了。有人提出它在因黄体期缺陷导致复发性流产的女性中可能发挥作用，但其疗效尚未得到证实。三项关于孕酮治疗复发性流产女性的对照试验表明，治疗组中持续超过20周的妊娠率有小幅上升，但无统计学意义。这些研究均没有足够的统计学效力来检测出结局方面具有临床意义的改善，但使用荟萃分析原理汇总这些研究结果后，可以计算出治疗的总体效果。妊娠至少达到20周的比值比为3.09（95%可信区间为1.28至7.42），这表明有证据支持以下观点：妊娠早期给予孕酮对复发性流产女性有用。不过，在以这种方式使用孕酮之前，必须根据该荟萃分析的结果，在前瞻性双盲随机对照试验中评估其对因黄体期缺陷导致复发性流产女性的疗效。
