Dicke K A, Spinolo J A
Bone Marrow Transplantation Section, University of Texas, M.D. Anderson Cancer Center, Houston.
Bone Marrow Transplant. 1989 Jan;4 Suppl 1:184-6.
Multiple clinical studies have been undertaken to evaluate the role of ABMT in relapse, in second and subsequent remission (CR greater than or equal to 2), and in first remission (CR1). The value of these high dose cytoreductive programs with ABMT is not yet known. No randomized studies have been done yet indicating that ABMT is superior to conventional dose chemotherapy. Besides, the diversity of regimens and patient populations make evaluation of results extremely difficult. When these variables are taken into account, the effect of purging on the clinical results becomes unclear. Multiple methods of purging have been devised, and several clinical trials have been reported. Although the biological role of purging is still unknown, theoretical considerations will be discussed and recommendations of patient subpopulations in which purging might be effective will be given.
已经开展了多项临床研究，以评估自体骨髓移植（ABMT）在复发、第二次及后续缓解期（完全缓解（CR）大于或等于2）以及首次缓解期（CR1）中的作用。这些采用ABMT的高剂量细胞减灭方案的价值尚不清楚。目前尚未进行随机研究表明ABMT优于传统剂量化疗。此外，方案和患者群体的多样性使得结果评估极其困难。当考虑到这些变量时，净化对临床结果的影响就变得不明确了。已经设计了多种净化方法，并且已经报道了多项临床试验。尽管净化的生物学作用仍然未知，但将讨论理论上的考虑因素，并给出可能有效的净化患者亚群的建议。
