Yang Seung-Ae
College of Nursing, Sungshin Women's University, Seoul, Korea.
J Exerc Rehabil. 2015 Oct 30;11(5):282-6. doi: 10.12965/jer.150239. eCollection 2015 Oct.
The aim of this study is to investigate the relationship between single nucleotide polymorphisms (SNPs) and susceptibility to obesity. A previous study suggested that insulin-like growth factors (IGFs) may affect obesity and that IGFs regulate cellular signals by receptors that include the insulin-like growth factor 1 receptor (IGF1R) and the insulin-like growth factor 2 receptor (IGF2R). In this research, the rs3743262 and rs2229765 SNPs of IGF1R gene and rs629849 and rs1805075 SNPs of IG-F2R gene were genotyped in 120 overweight and obese patients with a BMI≥23 kg/m2 (Body Mass Index) and 123 healthy controls with a BMI of 18.5-23.0 kg/m2. Genotyping of each SNP was performed by direct sequencing. Among tested SNPs in IGF1R and IGF2R genes, rs629849 SNP of IGF2R gene showed significant association with obesity (OR=1.86, 95% CI=1.02-3.40, P=0.044 in codominant1 model; OR=1.99, 95% CI=1.10-3.57, P=0.020 in dominant model; OR=1.93, 95% CI=1.13-3.31, P=0.013 in log-additive model). And allele distribution between the control group and overweight/obese group also showed significant difference (OR=1.93, 95% CI=1.14-3.28, P=0.015). In conclusion, these results indicate that rs629849 SNP of IGF2R might be contributed to development of obesity in the Korean population.
本研究的目的是调查单核苷酸多态性（SNP）与肥胖易感性之间的关系。先前的一项研究表明，胰岛素样生长因子（IGF）可能影响肥胖，并且IGF通过包括胰岛素样生长因子1受体（IGF1R）和胰岛素样生长因子2受体（IGF2R）的受体调节细胞信号。在本研究中，对120名体重指数（BMI）≥23kg/m²的超重和肥胖患者以及123名BMI为18.5 - 23.0kg/m²的健康对照者进行了IGF1R基因的rs3743262和rs2229765 SNP以及IGF2R基因的rs629849和rs1805075 SNP的基因分型。每个SNP的基因分型通过直接测序进行。在IGF1R和IGF2R基因的测试SNP中，IGF2R基因的rs629849 SNP与肥胖显著相关（共显性1模型中，OR = 1.86，95%CI = 1.02 - 3.40，P = 0.044；显性模型中，OR = 1.99，95%CI = 1.10 - 3.57，P = 0.020；对数加性模型中，OR = 1.93，95%CI = 1.13 - 3.31，P = 0.013）。并且对照组与超重/肥胖组之间的等位基因分布也显示出显著差异（OR = 1.93，95%CI = 1.14 - 3.28，P = 0.015）。总之，这些结果表明IGF2R基因的rs629849 SNP可能与韩国人群肥胖的发生有关。
