Department of Physiology, College of Liberal Arts, University of Minnesota, Minneapolis, Minnesota, USA.
J Interferon Cytokine Res. 2012 Sep;32(9):401-6. doi: 10.1089/jir.2011.0084. Epub 2012 Aug 21.
This study investigated whether insulin-like growth factor 1 receptor (IGF1R) single-nucleotide polymorphisms (SNPs) are associated with the development of papillary thyroid cancer (PTC) and their clinicopathologic features in the Korean population. One hundred and five PTC patients and 312 control subjects were enrolled. Two exonic SNPs (rs3743262, Thr766Thr; rs2229765, Glu1043Glu) in IGF1R were genotyped using direct sequencing. SNPStats, SPSS 18.0, and Haploview version 4.2 programs were used to evaluate genetic data. Multiple logistic regression models were used to determine odds ratios (ORs), 95% confidence intervals (CIs), and P values. A SNP (rs2229765) was associated with the development of PTC (OR = 0.56, 95% CI = 0.35-0.89, P = 0.016 in a codominant model 1; OR = 0.29, 95% CI = 0.11-0.78, P = 0.012 in a codominant model 2; OR = 0.51, 95% CI = 0.32-0.79, P = 0.0028 in a dominant model; OR = 0.38, 95% CI = 0.15-1.01, P = 0.031 in a recessive model; OR = 0.55, 95% CI = 0.38-0.80, P = 0.0001 in a log-additive model; OR = 1.78, 95% CI = 1.25-2.54, P = 0.002 in allele distribution). Our data suggest that the IGF1R may be a risk factor of susceptibility in PTC.
这项研究旨在探讨胰岛素样生长因子 1 受体 (IGF1R) 单核苷酸多态性 (SNP) 是否与韩国人群中甲状腺乳头状癌 (PTC) 的发生及其临床病理特征相关。本研究共纳入 105 例 PTC 患者和 312 例对照。采用直接测序法检测 IGF1R 中两个外显子 SNP(rs3743262，Thr766Thr; rs2229765，Glu1043Glu)的基因型。使用 SNPStats、SPSS 18.0 和 Haploview 版本 4.2 程序来评估遗传数据。采用多因素逻辑回归模型来确定比值比（OR）、95%置信区间（CI）和 P 值。一个 SNP(rs2229765)与 PTC 的发生相关（在显性模型中，OR=0.56，95%CI=0.35-0.89，P=0.016；OR=0.29，95%CI=0.11-0.78，P=0.012；OR=0.51，95%CI=0.32-0.79，P=0.0028；OR=0.38，95%CI=0.15-1.01，P=0.031；OR=0.55，95%CI=0.38-0.80，P=0.0001；OR=1.78，95%CI=1.25-2.54，P=0.002 在等位基因分布中）。我们的数据表明，IGF1R 可能是 PTC 易感性的一个危险因素。
