South Carolina Orthopaedic Institute, Orangeburg, South Carolina, USA.
UHealth Sports Performance and Wellness Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA. ; Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Orthop J Sports Med. 2014 Feb 6;2(2):2325967113519935. doi: 10.1177/2325967113519935. eCollection 2014 Feb.
The treatment of sports-related musculoskeletal injuries with stem cells has become more publicized because of recent reports of high-profile athletes undergoing stem cell procedures. There has been increased interest in defining the parameters of safety and efficacy and the indications for potential use of stem cells in clinical practice.
To review the role of regenerative medicine in the treatment of sports-related injuries.
Review.
Relevant studies were identified through a PubMed search combining the terms stem cells and cartilage, ligament, tendon, muscle, and bone from January 2000 to August 2013. Studies and works cited in these studies were also reviewed.
Treatment of sports-related injuries with stem cells shows potential for clinical efficacy from the data available from basic science and animal studies.
Cell-based therapies and regenerative medicine offer safe and potentially efficacious treatment for sports-related musculoskeletal injuries. Basic science and preclinical studies that support the possibility of enhanced recovery from sports injuries using cell-based therapies are accumulating; however, more clinical evidence is necessary to define the indications and parameters for their use. Accordingly, exposing patients to cell-based therapies could confer an unacceptable risk profile with minimal or no benefit. Continued clinical testing with animal models and clinical trials is necessary to determine the relative risks and benefits as well as the indications and methodology of treatment.
由于最近有报道称一些知名运动员接受了干细胞治疗，因此，干细胞在治疗与运动相关的肌肉骨骼损伤方面的应用变得更加普及。人们越来越关注确定干细胞在临床实践中的安全性、有效性和潜在用途的参数和适应证。
综述再生医学在治疗与运动相关的损伤中的作用。
回顾性研究。
通过在 PubMed 上搜索 2000 年 1 月至 2013 年 8 月间使用“stem cells”和“cartilage，ligament，tendon，muscle，bone”组合术语的相关研究，对再生医学在治疗与运动相关的损伤中的作用进行综述。同时也对这些研究中的相关研究和参考文献进行了回顾。
从基础科学和动物研究现有的数据来看，用干细胞治疗与运动相关的损伤显示出具有临床疗效的潜力。
基于细胞的治疗和再生医学为治疗与运动相关的肌肉骨骼损伤提供了安全且可能有效的治疗方法。支持使用基于细胞的治疗方法从运动损伤中获得更好恢复的基础科学和临床前研究正在不断增加；但是，还需要更多的临床证据来确定其适应证和参数。因此，让患者接受基于细胞的治疗方法可能会带来不可接受的风险，而获益甚微或没有获益。有必要继续在动物模型和临床试验中进行临床测试，以确定相对风险和获益，以及治疗的适应证和方法。
