Atarbashi Moghadam Saede, Lotfi Ali, Piroozhashemi Batool, Mokhtari Sepideh
Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dentist, Private Practice, Tehran, Iran.
J Dent (Shiraz). 2015 Sep;16(3 Suppl):274-277..
Langerhans cell histiocytosis is a rare disease with unknown pathogenesis and is characterized by local or disseminated proliferation of Langerhans cells. There is no previous investigation on prevalence of oral Langerhans cell histiocytosis in Iranian population.
The purpose of this study was to assess the relative frequency of oral Langerhans cell histiocytosis in an Iranian population and to compare the data with previous reports.
Pathology files of Oral and Maxillofacial Pathology Department of Dental School of Shahid Beheshti University of Medical Sciences from 1992 to 2012 were searched for cases recorded as oral Langerhans cell histiocytosis. A total number of 20 cases were found and the clinical information of patients was recorded.
The relative frequency of oral Langerhans cell histiocytosis was 0.34% and the most common location was the posterior mandible. In addition, the mean age of patients was 27 years and there was a definite male predominance. Most lesions were localized and tooth mobility was the most common oral presentation.
In Iranian population as in many other countries, the relative frequency of oral Langerhans cell histiocytosis is low. Moreover, tooth mobility and periodontal lesions are the frequent early signs of disease. Therefore, in patients with periodontal problems, good oral health, and no response to the treatment; Langerhans cell histiocytosis must be considered. Additionally, although most cases of oral Langerhans cell histiocytosis are localized, systemic involvement must also be considered and dental professionals have an important role in early detection of the disease.
朗格汉斯细胞组织细胞增多症是一种发病机制不明的罕见疾病，其特征为朗格汉斯细胞的局部或播散性增殖。此前尚无关于伊朗人群口腔朗格汉斯细胞组织细胞增多症患病率的调查。
本研究的目的是评估伊朗人群中口腔朗格汉斯细胞组织细胞增多症的相对发病率，并将数据与既往报告进行比较。
检索了1992年至2012年沙希德·贝赫什提医科大学牙科学院口腔颌面病理科的病理档案，查找记录为口腔朗格汉斯细胞组织细胞增多症的病例。共发现20例病例，并记录了患者的临床信息。
口腔朗格汉斯细胞组织细胞增多症的相对发病率为0.34%，最常见的部位是下颌骨后部。此外，患者的平均年龄为27岁，男性明显居多。大多数病变为局限性，牙齿松动是最常见的口腔表现。
与许多其他国家一样，在伊朗人群中，口腔朗格汉斯细胞组织细胞增多症的相对发病率较低。此外，牙齿松动和牙周病变是该病常见的早期体征。因此，对于有牙周问题、口腔健康良好且治疗无反应的患者，必须考虑朗格汉斯细胞组织细胞增多症。此外，尽管大多数口腔朗格汉斯细胞组织细胞增多症病例为局限性，但也必须考虑全身受累情况，牙科专业人员在该病的早期检测中发挥着重要作用。
