墨西哥人群中谷胱甘肽S-转移酶M1基因无效多态性与乳腺癌的关联。

Association of the GSTM1 null polymorphism with breast cancer in a Mexican population.

作者信息

Soto-Quintana O, Zúñiga-González G M, Ramírez-Patiño R, Ramos-Silva A, Figuera L E, Carrillo-Moreno D I, Gutiérrez-Hurtado I A, Puebla-Pérez A M, Sánchez-Llamas B, Gallegos-Arreola M P

机构信息

Molecular Genetics Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.

Mutagenesis Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.

出版信息

Genet Mol Res. 2015 Oct 26;14(4):13066-75. doi: 10.4238/2015.October.26.2.

DOI:10.4238/2015.October.26.2

PMID:26535619

Abstract

The glutathione S transferase (GST) family plays an important role in the processing of carcinogens. Data on the null GSTM1 genotype has revealed associations with cancer, and has been suggested to affect carcinogen metabolism and to contribute to tumor promotion in the mammary gland. We examined the role of the null GSTM1 genotype by comparing the genotypes of 276 healthy Mexican women with those of 558 Mexican women with breast cancer (BC). The genotype frequencies observed in the controls and patients with BC were 38 and 45% for the null GSTM1 genotype, respectively. The obtained odds ratio (OR) was 1.36, with a 95% confidence interval (95%CI) of 1.02-1.8, P = 0.04. The protective association was also evident upon analysis of the distributions of the null GSTM1 genotype in patients with positive chemotherapy response who had high plasma levels of glucose (OR 0.56, 95%CI = 0.33-0.94, P = 0.03). This study suggested that the null GSTM1 genotype is associated with BC susceptibility in the Mexican population analyzed.

摘要

谷胱甘肽S转移酶（GST）家族在致癌物的处理过程中发挥着重要作用。关于GSTM1基因无效型的数据已揭示其与癌症的关联，并有人提出它会影响致癌物代谢并促进乳腺肿瘤的发生。我们通过比较276名健康墨西哥女性与558名患有乳腺癌（BC）的墨西哥女性的基因型，研究了GSTM1基因无效型的作用。在对照组和BC患者中观察到的GSTM1基因无效型的基因型频率分别为38%和45%。获得的优势比（OR）为1.36，95%置信区间（95%CI）为1.02 - 1.8，P = 0.04。在对化疗反应呈阳性且血糖水平高的患者中分析GSTM1基因无效型的分布时，这种保护关联也很明显（OR 0.56，95%CI = 0.33 - 0.94，P = 0.03）。这项研究表明，在所分析的墨西哥人群中，GSTM1基因无效型与BC易感性相关。