Department of Nursing, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, 1 Cheng Bei Road, Jiading District, Shanghai, 201800, China.
Department of Scientific Research, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, 1 Cheng Bei Road, Jiading District, Shanghai, 201800, China.
Eur J Med Res. 2018 Jun 19;23(1):34. doi: 10.1186/s40001-018-0331-z.
It is reported that glutathione S-transferase mu (GSTM1) polymorphism is associated with non-viral hepatic cirrhosis (HC). However, some studies showed different views. Therefore, in this paper, a meta-analysis was conducted to get a more comprehensive understanding of GSTM1 polymorphisms in non-viral HC susceptibility. The results showed that GSTM1 null was associated with the increased risk of non-viral HC (OR = 1.337, 95% CI 1.112-1.804, p = 0.005). Subgroup analysis of cirrhosis type revealed that GSTM1 null was a prominent risk factor for alcoholic HC (OR = 1.416, 95% CI 1.112-1.804, p = 0.005). Meanwhile, subgroup analysis of population indicated that the significant differences only existed in Asian population (OR = 1.719, 95% CI 1.212-2.438, p = 0.002). In hospital-based studies, patients with GSTM1 null were more likely in risk of HC (OR = 1.426, 95% CI 1.092-1.863, p = 0.009). Subgroup analysis using genotyping method showed a significant association between GSTM1 null genotype and HC occurrence in the studies employing the multiple PCR genotyping method (OR = 1.559, 95% CI 1.171-2.076, p = 0.002). Based on the results of this analysis, it was concluded that GSTM1 null genotype could increase the susceptibility of non-viral hepatic cirrhosis. In addition, alcohol intake, Asian ethnicity, sample source from hospital and multiple PCR genotyping method may also influence the susceptibility of hepatic cirrhosis.
据报道，谷胱甘肽 S-转移酶 mu（GSTM1）多态性与非病毒性肝硬变（HC）有关。然而，一些研究显示出不同的观点。因此，本文进行了荟萃分析，以更全面地了解 GSTM1 多态性与非病毒性 HC 易感性的关系。结果表明，GSTM1 缺失与非病毒性 HC 的风险增加相关（OR=1.337，95%CI 1.112-1.804，p=0.005）。肝硬化类型的亚组分析表明，GSTM1 缺失是酒精性 HC 的一个显著危险因素（OR=1.416，95%CI 1.112-1.804，p=0.005）。同时，人群的亚组分析表明，仅在亚洲人群中存在显著差异（OR=1.719，95%CI 1.212-2.438，p=0.002）。在基于医院的研究中，GSTM1 缺失的患者发生 HC 的风险更高（OR=1.426，95%CI 1.092-1.863，p=0.009）。使用基因分型方法的亚组分析显示，在采用多重 PCR 基因分型方法的研究中，GSTM1 缺失基因型与 HC 发生之间存在显著关联（OR=1.559，95%CI 1.171-2.076，p=0.002）。基于该分析的结果，可以得出结论，GSTM1 缺失基因型可增加非病毒性肝硬变的易感性。此外，饮酒、亚洲种族、来自医院的样本来源和多重 PCR 基因分型方法也可能影响肝硬变的易感性。
